Title |
Anti-Inflammatory and Antinociceptive Activities of Untreated, Germinated, and Fermented Mung Bean Aqueous Extract
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Published in |
Evidence-based Complementary & Alternative Medicine (eCAM), June 2014
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DOI | 10.1155/2014/350507 |
Pubmed ID | |
Authors |
Norlaily Mohd Ali, Hamidah Mohd Yusof, Swee-Keong Yeap, Wan-Yong Ho, Boon-Kee Beh, Kamariah Long, Soo-Peng Koh, Mohd Puad Abdullah, Noorjahan Banu Alitheen |
Abstract |
Evaluation of anti-inflammatory and antinociceptive activities of untreated mung bean (MB), germinated mung bean (GMB), and fermented mung bean (FMB) was performed on both in vitro (inhibition of inflammatory mediator, nitric oxide(NO)) and in vivo (inhibition of ear oedema and reduction of response to pain stimulus) studies. Results showed that both GMB and FMB aqueous extract exhibited potent anti-inflammatory and antinociceptive activities in a dose-dependent manner. In vitro results showed that GMB and FMB were potent inflammatory mediator (NO) inhibitors at both 2.5 and 5 mg/mL. Further in vivo studies showed that GMB and FMB aqueous extract at 1000 mg/kg can significantly reduce ear oedema in mice caused by arachidonic acid. Besides, both 200 mg/kg and 1000 mg/kg concentrations of GMB and FMB were found to exhibit potent antinociceptive effects towards hotplate induced pain. With these, it can be concluded that GMB and FMB aqueous extract exhibited potential anti-inflammatory and antinociceptive effects. |
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Members of the public | 2 | 67% |
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Mendeley readers
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Student > Doctoral Student | 4 | 11% |
Student > Bachelor | 4 | 11% |
Professor > Associate Professor | 4 | 11% |
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Nursing and Health Professions | 2 | 6% |
Other | 3 | 8% |
Unknown | 14 | 39% |