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In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts of Lantana camara Leaves Collected from Tropical Region of Malaysia

Overview of attention for article published in Evidence-based Complementary & Alternative Medicine (eCAM), December 2015
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Title
In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts of Lantana camara Leaves Collected from Tropical Region of Malaysia
Published in
Evidence-based Complementary & Alternative Medicine (eCAM), December 2015
DOI 10.1155/2015/506413
Pubmed ID
Authors

Mallappa Kumara Swamy, Uma Rani Sinniah, Mohd. Sayeed Akhtar

Abstract

We investigated the effect of different solvents (ethyl acetate, methanol, acetone, and chloroform) on the extraction of phytoconstituents from Lantana camara leaves and their antioxidant and antibacterial activities. Further, GC-MS analysis was carried out to identify the bioactive chemical constituents occurring in the active extract. The results revealed the presence of various phytocompounds in the extracts. The methanol solvent recovered higher extractable compounds (14.4% of yield) and contained the highest phenolic (92.8 mg GAE/g) and flavonoid (26.5 mg RE/g) content. DPPH radical scavenging assay showed the IC50 value of 165, 200, 245, and 440 μg/mL for methanol, ethyl acetate, acetone, and chloroform extracts, respectively. The hydroxyl scavenging activity test showed the IC50 value of 110, 240, 300, and 510 μg/mL for methanol, ethyl acetate, acetone, and chloroform extracts, respectively. Gram negative bacterial pathogens (E. coli and K. pneumoniae) were more susceptible to all extracts compared to Gram positive bacteria (M. luteus, B. subtilis, and S. aureus). Methanol extract had the highest inhibition activity against all the tested microbes. Moreover, methanolic extract of L. camara contained 32 bioactive components as revealed by GC-MS study. The identified major compounds included hexadecanoic acid (5.197%), phytol (4.528%), caryophyllene oxide (4.605%), and 9,12,15-octadecatrienoic acid, methyl ester, (Z,Z,Z)- (3.751%).

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 146 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 18%
Student > Bachelor 22 15%
Student > Master 15 10%
Researcher 10 7%
Lecturer 7 5%
Other 19 13%
Unknown 47 32%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 18%
Pharmacology, Toxicology and Pharmaceutical Science 15 10%
Biochemistry, Genetics and Molecular Biology 14 10%
Chemistry 12 8%
Immunology and Microbiology 5 3%
Other 18 12%
Unknown 56 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2015.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Evidence-based Complementary & Alternative Medicine (eCAM)
#4,646
of 9,352 outputs
Outputs of similar age
#275,134
of 395,144 outputs
Outputs of similar age from Evidence-based Complementary & Alternative Medicine (eCAM)
#90
of 143 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,352 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,144 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 143 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.