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GC-MS Based Metabolite Profiling, Antioxidant and Antimicrobial Properties of Different Solvent Extracts of Malaysian Plectranthus amboinicus Leaves

Overview of attention for article published in Evidence-based Complementary & Alternative Medicine (eCAM), March 2017
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Title
GC-MS Based Metabolite Profiling, Antioxidant and Antimicrobial Properties of Different Solvent Extracts of Malaysian Plectranthus amboinicus Leaves
Published in
Evidence-based Complementary & Alternative Medicine (eCAM), March 2017
DOI 10.1155/2017/1517683
Pubmed ID
Authors

Mallappa Kumara Swamy, Greetha Arumugam, Ravinder Kaur, Ali Ghasemzadeh, Mazina Mohd. Yusoff, Uma Rani Sinniah

Abstract

This study evaluates the phytochemistry, antioxidant, and antimicrobial effects of Plectranthus amboinicus leaves extracted in different solvents. The methanol extract contained the highest total phenolic (94.37 ± 1.24 mg GAE/g) and flavonoid contents (26.90 ± 1.35 mg RE/g) and exhibited the highest DPPH scavenging activity (90.13 ± 3.32%) followed by the acetone extract (80.23 ± 3.26%) at 500 μg/mL concentration. Similarly, the highest ferric ion reduction potential (849.63 ± 30.95 μM of Fe (II)/g dry weight) was exhibited by the methanol extract followed by the acetone extract (695.92 ± 25.44 μM of Fe (II)/g dry weight). The methanol extract showed greater antimicrobial activity against all the tested pathogens (Bacillus subtilis, Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans). However, both hexane and acetone extracts failed to inhibit E. coli. S. aureus and C. albicans were more susceptible to all the extracts. Further, GC-MS analysis confirmed the occurrence of a total 46 phytocompounds in different solvent extracts. Some of the major compounds included carvacrol (37.7%), tetracontane (16.6%), squalene (15.6%), tetrapentacontane (13.7%), and Phytol (12.9%). In conclusion, extraction solvents influenced the recovery of phytocompounds and the highest pharmacological activities of the methanol extract could be correlated to the presence of additional bioactive compounds.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 243 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 243 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 16%
Student > Bachelor 31 13%
Student > Master 24 10%
Researcher 16 7%
Lecturer 10 4%
Other 30 12%
Unknown 93 38%
Readers by discipline Count As %
Agricultural and Biological Sciences 52 21%
Biochemistry, Genetics and Molecular Biology 24 10%
Chemistry 19 8%
Pharmacology, Toxicology and Pharmaceutical Science 11 5%
Medicine and Dentistry 9 4%
Other 23 9%
Unknown 105 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2017.
All research outputs
#15,742,933
of 25,382,440 outputs
Outputs from Evidence-based Complementary & Alternative Medicine (eCAM)
#3,003
of 9,351 outputs
Outputs of similar age
#179,151
of 322,668 outputs
Outputs of similar age from Evidence-based Complementary & Alternative Medicine (eCAM)
#40
of 144 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,351 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,668 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 144 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.