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Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy

Overview of attention for article published in Discover Nano, November 2016
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Title
Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy
Published in
Discover Nano, November 2016
DOI 10.1186/s11671-016-1712-2
Pubmed ID
Authors

Dena Dorniani, Bullo Saifullah, Farahnaz Barahuie, Palanisamy Arulselvan, Mohd Zobir Bin Hussein, Sharida Fakurazi, Lance J. Twyman

Abstract

Despite the technological advancement in the biomedical science, cancer remains a life-threatening disease. In this study, we designed an anticancer nanodelivery system using graphene oxide (GO) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (GOGA) was characterized using XRD, FTIR, HRTEM, Raman, and UV/Vis spectroscopy. The release study shows that the release of GA from the designed anticancer nanocomposite (GOGA) occurs in a sustained manner in phosphate-buffered saline (PBS) solution at pH 7.4. In in vitro biological studies, normal fibroblast (3T3) and liver cancer cells (HepG2) were treated with different concentrations of GO, GOGA, and GA for 72 h. The GOGA nanocomposite showed the inhibitory effect to cancer cell growth without affecting normal cell growth. The results of this research are highly encouraging to go further for in vivo studies.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 96 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 15%
Researcher 13 14%
Student > Bachelor 11 11%
Student > Ph. D. Student 10 10%
Student > Doctoral Student 5 5%
Other 12 13%
Unknown 31 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 13%
Chemistry 11 11%
Materials Science 8 8%
Pharmacology, Toxicology and Pharmaceutical Science 6 6%
Chemical Engineering 5 5%
Other 19 20%
Unknown 35 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2022.
All research outputs
#16,048,009
of 25,374,917 outputs
Outputs from Discover Nano
#501
of 1,146 outputs
Outputs of similar age
#188,179
of 319,094 outputs
Outputs of similar age from Discover Nano
#13
of 18 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,146 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,094 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.