Title |
Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle Disease Virus outbreak in West Malaysia
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Published in |
BMC Veterinary Research, August 2015
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DOI | 10.1186/s12917-015-0537-z |
Pubmed ID | |
Authors |
Seetha Jaganathan, Peck Toung Ooi, Lai Yee Phang, Zeenathul Nazariah Binti Allaudin, Lai Siong Yip, Pow Yoon Choo, Ban Keong Lim, Stephane Lemiere, Jean-Christophe Audonnet |
Abstract |
Newcastle disease virus remains a constant threat in commercial poultry farms despite intensive vaccination programs. Outbreaks attributed to ND can escalate and spread across farms and states contributing to major economic loss in poultry farms. Phylogenetic analysis in our study showed that eleven of the samples belonged to genotype VIId. All farms were concurrently positive with two immunosuppressive viruses; Infectious Bursal Disease Virus (IBDV) and Marek's Disease Virus (MDV). Amino acid sequence analysis confirmed that eleven of the samples had sequence motifs for velogenic/mesogenic strains; three were lentogenic. In conclusion, no new NDV genotype was isolated from the 2011 NDV outbreak. This study suggests that the presence of other immunosuppressive agents such as IBD and MDV could have contributed to the dysfunction of the immune system of the chickens, causing severe NDV outbreaks in 2011. Risk factors related to biosecurity and farm practices appear to have a significant role in the severity of the disease observed in affected farms. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 11 | 20% |
Student > Ph. D. Student | 9 | 17% |
Student > Doctoral Student | 7 | 13% |
Student > Master | 7 | 13% |
Researcher | 3 | 6% |
Other | 7 | 13% |
Unknown | 10 | 19% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 19 | 35% |
Agricultural and Biological Sciences | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Immunology and Microbiology | 4 | 7% |
Medicine and Dentistry | 3 | 6% |
Other | 5 | 9% |
Unknown | 10 | 19% |