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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin
|
|---|---|
| Published in |
International Journal of Nanomedicine, July 2013
|
| DOI | 10.2147/ijn.s42367 |
| Pubmed ID | |
| Authors |
Mothanna Sadiq Al-Qubaisi, Abdullah Rasedee, Moayad Husein Flaifel, Sahrim HJ Ahmad, Samer Hussein-Al-Ali, Mohd Zobir Hussein, Eltayeb EM Eid, Zulkarnain Zainal, Mohd Saeed, Muna Ilowefah, Sharida Fakurazi, Norhaszalina Mohd Isa, Mohamed Ezzat El Zowalaty |
| Abstract |
In this study, in vitro cytotoxicity of nickel zinc (NiZn) ferrite nanoparticles against human colon cancer HT29, breast cancer MCF7, and liver cancer HepG2 cells was examined. The morphology, homogeneity, and elemental composition of NiZn ferrite nanoparticles were investigated by scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy, respectively. The exposure of cancer cells to NiZn ferrite nanoparticles (15.6-1,000 μg/mL; 72 hours) has resulted in a dose-dependent inhibition of cell growth determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The quantification of caspase-3 and -9 activities and DNA fragmentation to assess the cell death pathway of the treated cells showed that both were stimulated when exposed to NiZn ferrite nanoparticles. Light microscopy examination of the cells exposed to NiZn ferrite nanoparticles demonstrated significant changes in cellular morphology. The HepG2 cells were most prone to apoptosis among the three cells lines examined, as the result of treatment with NiZn nanoparticles. In conclusion, NiZn ferrite nanoparticles are suggested to have potential cytotoxicity against cancer cells. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 1% |
| Unknown | 86 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 21% |
| Researcher | 13 | 15% |
| Student > Master | 8 | 9% |
| Student > Bachelor | 7 | 8% |
| Professor > Associate Professor | 6 | 7% |
| Other | 19 | 22% |
| Unknown | 16 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Materials Science | 14 | 16% |
| Biochemistry, Genetics and Molecular Biology | 12 | 14% |
| Agricultural and Biological Sciences | 10 | 11% |
| Chemistry | 6 | 7% |
| Physics and Astronomy | 4 | 5% |
| Other | 18 | 21% |
| Unknown | 23 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 September 2013.
All research outputs
#15,879,822
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#1,779
of 4,077 outputs
Outputs of similar age
#117,973
of 207,028 outputs
Outputs of similar age from International Journal of Nanomedicine
#41
of 85 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,077 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,028 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.