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Mendeley readers
| Title |
Anti-Tumour Promoting Activity and Antioxidant Properties of Girinimbine Isolated from the Stem Bark of Murraya koenigii S
|
|---|---|
| Published in |
Molecules, April 2012
|
| DOI | 10.3390/molecules17044651 |
| Pubmed ID | |
| Authors |
Yih Yih Kok, Lim Yang Mooi, Kartini Ahmad, Mohd Aspollah Sukari, Nashriyah Mat, Mawardi Rahmani, Abdul Manaf Ali |
| Abstract |
Girinimbine, a carbazole alkaloid isolated from the stem bark of Murraya koenigii was tested for the in vitro anti-tumour promoting and antioxidant activities. Anti-tumour promoting activity was determined by assaying the capability of this compound to inhibit the expression of early antigen of Epstein-Barr virus (EA-EBV) in Raji cells that was induced by the tumour promoter, phorbol 12-myristate 13-acetate. The concentration of this compound that gave an inhibition rate at fifty percent was 6.0 µg/mL and was not cytotoxic to the cells. Immunoblotting analysis of the expression of EA-EBV showed that girinimbine was able to suppress restricted early antigen (EA-R). However, diffused early antigen (EA-D) was partially suppressed when used at 32.0 µg/mL. Girinimbine exhibited a very strong antioxidant activity as compared to a-tocopherol and was able to inhibit superoxide generation in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiated premyelocytic HL-60 cells more than 95%, when treated with the compound at 5.3 and 26.3 µg/mL, respectively. However girinimbine failed to scavenge the stable diphenyl picryl hydrazyl (DPPH)-free radical. |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | 3% |
| Malaysia | 1 | 3% |
| Algeria | 1 | 3% |
| India | 1 | 3% |
| Unknown | 28 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 25% |
| Student > Bachelor | 7 | 22% |
| Student > Master | 3 | 9% |
| Other | 2 | 6% |
| Lecturer > Senior Lecturer | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 10 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 28% |
| Agricultural and Biological Sciences | 3 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Unspecified | 1 | 3% |
| Medicine and Dentistry | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 15 | 47% |