Title |
Antistress and antioxidant effects of virgin coconut oil in vivo
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Published in |
Experimental and Therapeutic Medicine, November 2014
|
DOI | 10.3892/etm.2014.2045 |
Pubmed ID | |
Authors |
SWEE KEONG YEAP, BOON KEE BEH, NORLAILY MOHD ALI, HAMIDAH MOHD YUSOF, WAN YONG HO, SOO PENG KOH, NOORJAHAN BANU ALITHEEN, KAMARIAH LONG |
Abstract |
Virgin coconut oil (VCO) has been consumed worldwide for various health-related reasons and some of its benefits have been scientifically evaluated. Medium-chain fatty acids were found to be a potential antidepressant functional food; however, this effect had not been evaluated in VCO, which is rich in polyphenols and medium-chain fatty acids. The aim of this study was to evaluate the antistress and antioxidant effects of VCO in vivo, using mice with stress-induced injury. The antistress effect of VCO (administered per os, at a dose of 10 ml/kg body weight) was evaluated using the forced swim test and chronic cold restraint stress models. VCO was able to reduce immobility time and restore oxidative stress in mice post-swim test. Furthermore, mice treated with VCO were found to exhibit higher levels of brain antioxidants, lower levels of brain 5-hydroxytryptamine and reduced weight of the adrenal glands. Consequently, the serum cholesterol, triglyceride, glucose and corticosterone levels were also lower in VCO-treated mice. These results suggest the potential value of VCO as an antistress functional oil. |
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Mendeley readers
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Demographic breakdown
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Student > Master | 26 | 10% |
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Researcher | 15 | 6% |
Other | 13 | 5% |
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Unknown | 82 | 33% |
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Pharmacology, Toxicology and Pharmaceutical Science | 14 | 6% |
Other | 44 | 18% |
Unknown | 92 | 37% |