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Protective effects of the extracts of Barringtonia racemosa shoots against oxidative damage in HepG2 cells

Overview of attention for article published in PeerJ, January 2016
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Title
Protective effects of the extracts of Barringtonia racemosa shoots against oxidative damage in HepG2 cells
Published in
PeerJ, January 2016
DOI 10.7717/peerj.1628
Pubmed ID
Authors

Kin Weng Kong, Sarni Mat-Junit, Norhaniza Aminudin, Fouad Abdulrahman Hassan, Amin Ismail, Azlina Abdul Aziz

Abstract

Barringtonia racemosa is a tropical plant with medicinal values. In this study, the ability of the water extracts of the leaf (BLE) and stem (BSE) from the shoots to protect HepG2 cells against oxidative damage was studied. Five major polyphenolic compounds consisting of gallic acid, ellagic acid, protocatechuic acid, quercetin and kaempferol were identified using HPLC-DAD and ESI-MS. Cell viability assay revealed that BLE and BSE were non-cytotoxic (cell viabilities >80%) at concentration less than 250 µg/ml and 500 µg/ml, respectively. BLE and BSE improved cellular antioxidant status measured by FRAP assay and protected HepG2 cells against H2O2-induced cytotoxicity. The extracts also inhibited lipid peroxidation in HepG2 cells as well as the production of reactive oxygen species. BLE and BSE could also suppress the activities of superoxide dismutase and catalase during oxidative stress. The shoots of B. racemosa can be an alternative bioactive ingredient in the prevention of oxidative damage.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mauritius 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 17%
Student > Bachelor 5 17%
Researcher 4 14%
Student > Master 3 10%
Lecturer > Senior Lecturer 2 7%
Other 4 14%
Unknown 6 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 28%
Pharmacology, Toxicology and Pharmaceutical Science 4 14%
Biochemistry, Genetics and Molecular Biology 3 10%
Medicine and Dentistry 3 10%
Computer Science 1 3%
Other 2 7%
Unknown 8 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2016.
All research outputs
#17,783,561
of 22,842,950 outputs
Outputs from PeerJ
#10,114
of 13,280 outputs
Outputs of similar age
#270,063
of 396,720 outputs
Outputs of similar age from PeerJ
#253
of 289 outputs
Altmetric has tracked 22,842,950 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,280 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.4. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,720 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 289 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.