| Title |
Miniature Neurotransmission Regulates Drosophila Synaptic Structural Maturation
|
|---|---|
| Published in |
Neuron, May 2014
|
| DOI | 10.1016/j.neuron.2014.03.012 |
| Pubmed ID | |
| Authors |
Ben Jiwon Choi, Wendy L. Imlach, Wei Jiao, Verena Wolfram, Ying Wu, Mark Grbic, Carolina Cela, Richard A. Baines, Michael N. Nitabach, Brian D. McCabe |
| Abstract |
Miniature neurotransmission is the transsynaptic process where single synaptic vesicles spontaneously released from presynaptic neurons induce miniature postsynaptic potentials. Since their discovery over 60 years ago, miniature events have been found at every chemical synapse studied. However, the in vivo necessity for these small-amplitude events has remained enigmatic. Here, we show that miniature neurotransmission is required for the normal structural maturation of Drosophila glutamatergic synapses in a developmental role that is not shared by evoked neurotransmission. Conversely, we find that increasing miniature events is sufficient to induce synaptic terminal growth. We show that miniature neurotransmission acts locally at terminals to regulate synapse maturation via a Trio guanine nucleotide exchange factor (GEF) and Rac1 GTPase molecular signaling pathway. Our results establish that miniature neurotransmission, a universal but often-overlooked feature of synapses, has unique and essential functions in vivo. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 19% |
| Ireland | 2 | 13% |
| Switzerland | 1 | 6% |
| United Kingdom | 1 | 6% |
| Italy | 1 | 6% |
| Unknown | 8 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 88% |
| Scientists | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Chile | 1 | <1% |
| Australia | 1 | <1% |
| Italy | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 209 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 74 | 34% |
| Researcher | 35 | 16% |
| Student > Master | 19 | 9% |
| Student > Bachelor | 19 | 9% |
| Student > Doctoral Student | 10 | 5% |
| Other | 33 | 15% |
| Unknown | 28 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 86 | 39% |
| Neuroscience | 72 | 33% |
| Biochemistry, Genetics and Molecular Biology | 13 | 6% |
| Medicine and Dentistry | 7 | 3% |
| Psychology | 2 | <1% |
| Other | 7 | 3% |
| Unknown | 31 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 59. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2014.
All research outputs
#716,711
of 25,374,647 outputs
Outputs from Neuron
#1,337
of 9,545 outputs
Outputs of similar age
#6,565
of 242,177 outputs
Outputs of similar age from Neuron
#20
of 116 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,545 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.2. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,177 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.