| Title |
Life Extension Factor Klotho Enhances Cognition
|
|---|---|
| Published in |
Cell Reports, May 2014
|
| DOI | 10.1016/j.celrep.2014.03.076 |
| Pubmed ID | |
| Authors |
Dena B. Dubal, Jennifer S. Yokoyama, Lei Zhu, Lauren Broestl, Kurtresha Worden, Dan Wang, Virginia E. Sturm, Daniel Kim, Eric Klein, Gui-Qiu Yu, Kaitlyn Ho, Kirsten E. Eilertson, Lei Yu, Makoto Kuro-o, Philip L. De Jager, Giovanni Coppola, Gary W. Small, David A. Bennett, Joel H. Kramer, Carmela R. Abraham, Bruce L. Miller, Lennart Mucke |
| Abstract |
Aging is the primary risk factor for cognitive decline, an emerging health threat to aging societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. We show that a lifespan-extending variant of the human KLOTHO gene, KL-VS, is associated with enhanced cognition in heterozygous carriers. Because this allele increased klotho levels in serum, we analyzed transgenic mice with systemic overexpression of klotho. They performed better than controls in multiple tests of learning and memory. Elevating klotho in mice also enhanced long-term potentiation, a form of synaptic plasticity, and enriched synaptic GluN2B, an N-methyl-D-aspartate receptor (NMDAR) subunit with key functions in learning and memory. Blockade of GluN2B abolished klotho-mediated effects. Surprisingly, klotho effects were evident also in young mice and did not correlate with age in humans, suggesting independence from the aging process. Augmenting klotho or its effects may enhance cognition and counteract cognitive deficits at different life stages. |
X Demographics
The data shown below were collected from the profiles of 56 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 34% |
| United Kingdom | 2 | 4% |
| France | 2 | 4% |
| Netherlands | 1 | 2% |
| Greece | 1 | 2% |
| Kuwait | 1 | 2% |
| Canada | 1 | 2% |
| India | 1 | 2% |
| Italy | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 26 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 40 | 71% |
| Scientists | 13 | 23% |
| Practitioners (doctors, other healthcare professionals) | 3 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 356 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| United Kingdom | 4 | 1% |
| France | 3 | <1% |
| Germany | 2 | <1% |
| Netherlands | 1 | <1% |
| Brazil | 1 | <1% |
| Sweden | 1 | <1% |
| Spain | 1 | <1% |
| Singapore | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 336 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 66 | 19% |
| Student > Ph. D. Student | 57 | 16% |
| Student > Master | 37 | 10% |
| Student > Bachelor | 33 | 9% |
| Other | 25 | 7% |
| Other | 70 | 20% |
| Unknown | 68 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 104 | 29% |
| Medicine and Dentistry | 44 | 12% |
| Neuroscience | 42 | 12% |
| Biochemistry, Genetics and Molecular Biology | 39 | 11% |
| Psychology | 18 | 5% |
| Other | 32 | 9% |
| Unknown | 77 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 501. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#52,657
of 25,756,911 outputs
Outputs from Cell Reports
#60
of 13,236 outputs
Outputs of similar age
#337
of 242,630 outputs
Outputs of similar age from Cell Reports
#1
of 184 outputs
Altmetric has tracked 25,756,911 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
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