| Title |
Long-Term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients
|
|---|---|
| Published in |
Cell Reports, June 2014
|
| DOI | 10.1016/j.celrep.2014.05.027 |
| Pubmed ID | |
| Authors |
Penelope J. Hallett, Oliver Cooper, Damaso Sadi, Harold Robertson, Ivar Mendez, Ole Isacson |
| Abstract |
To determine the long-term health and function of transplanted dopamine neurons in Parkinson's disease (PD) patients, the expression of dopamine transporters (DATs) and mitochondrial morphology were examined in human fetal midbrain cellular transplants. DAT was robustly expressed in transplanted dopamine neuron terminals in the reinnervated host putamen and caudate for at least 14 years after transplantation. The transplanted dopamine neurons showed a healthy and nonatrophied morphology at all time points. Labeling of the mitochondrial outer membrane protein Tom20 and α-synuclein showed a typical cellular pathology in the patients' own substantia nigra, which was not observed in transplanted dopamine neurons. These results show that the vast majority of transplanted neurons remain healthy for the long term in PD patients, consistent with clinical findings that fetal dopamine neuron transplants maintain function for up to 15-18 years in patients. These findings are critically important for the rational development of stem-cell-based dopamine neuronal replacement therapies for PD. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 36% |
| United Kingdom | 2 | 8% |
| Brazil | 1 | 4% |
| South Africa | 1 | 4% |
| Canada | 1 | 4% |
| Italy | 1 | 4% |
| Chile | 1 | 4% |
| Portugal | 1 | 4% |
| Japan | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 7 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 76% |
| Scientists | 3 | 12% |
| Science communicators (journalists, bloggers, editors) | 3 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| United Kingdom | 2 | <1% |
| Germany | 1 | <1% |
| India | 1 | <1% |
| Australia | 1 | <1% |
| Chile | 1 | <1% |
| China | 1 | <1% |
| Belgium | 1 | <1% |
| Spain | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 204 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 48 | 22% |
| Researcher | 42 | 19% |
| Student > Master | 27 | 12% |
| Student > Bachelor | 26 | 12% |
| Other | 11 | 5% |
| Other | 38 | 17% |
| Unknown | 26 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 64 | 29% |
| Neuroscience | 48 | 22% |
| Biochemistry, Genetics and Molecular Biology | 32 | 15% |
| Medicine and Dentistry | 24 | 11% |
| Engineering | 10 | 5% |
| Other | 17 | 8% |
| Unknown | 23 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 216. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2018.
All research outputs
#181,112
of 25,587,485 outputs
Outputs from Cell Reports
#232
of 13,118 outputs
Outputs of similar age
#1,408
of 243,171 outputs
Outputs of similar age from Cell Reports
#5
of 178 outputs
Altmetric has tracked 25,587,485 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,118 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.2. This one has done particularly well, scoring higher than 98% of its peers.
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