| Title |
Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity
|
|---|---|
| Published in |
Cell, December 2014
|
| DOI | 10.1016/j.cell.2014.11.005 |
| Pubmed ID | |
| Authors |
Anita Öst, Adelheid Lempradl, Eduard Casas, Melanie Weigert, Theodor Tiko, Merdin Deniz, Lorena Pantano, Ulrike Boenisch, Pavel M. Itskov, Marlon Stoeckius, Marius Ruf, Nikolaus Rajewsky, Gunter Reuter, Nicola Iovino, Carlos Ribeiro, Mattias Alenius, Steffen Heyne, Tanya Vavouri, J. Andrew Pospisilik |
| Abstract |
The global rise in obesity has revitalized a search for genetic and epigenetic factors underlying the disease. We present a Drosophila model of paternal-diet-induced intergenerational metabolic reprogramming (IGMR) and identify genes required for its encoding in offspring. Intriguingly, we find that as little as 2 days of dietary intervention in fathers elicits obesity in offspring. Paternal sugar acts as a physiological suppressor of variegation, desilencing chromatin-state-defined domains in both mature sperm and in offspring embryos. We identify requirements for H3K9/K27me3-dependent reprogramming of metabolic genes in two distinct germline and zygotic windows. Critically, we find evidence that a similar system may regulate obesity susceptibility and phenotype variation in mice and humans. The findings provide insight into the mechanisms underlying intergenerational metabolic reprogramming and carry profound implications for our understanding of phenotypic variation and evolution. |
X Demographics
The data shown below were collected from the profiles of 158 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 32 | 20% |
| United Kingdom | 11 | 7% |
| Spain | 10 | 6% |
| Canada | 8 | 5% |
| Germany | 6 | 4% |
| Australia | 5 | 3% |
| France | 3 | 2% |
| Netherlands | 2 | 1% |
| Switzerland | 2 | 1% |
| Other | 15 | 9% |
| Unknown | 64 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 84 | 53% |
| Scientists | 50 | 32% |
| Practitioners (doctors, other healthcare professionals) | 21 | 13% |
| Science communicators (journalists, bloggers, editors) | 3 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 639 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 2% |
| United Kingdom | 4 | <1% |
| Netherlands | 2 | <1% |
| Brazil | 2 | <1% |
| Sweden | 2 | <1% |
| Japan | 2 | <1% |
| China | 2 | <1% |
| France | 1 | <1% |
| Germany | 1 | <1% |
| Other | 7 | 1% |
| Unknown | 603 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 146 | 23% |
| Student > Ph. D. Student | 139 | 22% |
| Student > Bachelor | 79 | 12% |
| Student > Master | 58 | 9% |
| Professor > Associate Professor | 36 | 6% |
| Other | 110 | 17% |
| Unknown | 71 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 269 | 42% |
| Biochemistry, Genetics and Molecular Biology | 165 | 26% |
| Medicine and Dentistry | 46 | 7% |
| Neuroscience | 23 | 4% |
| Nursing and Health Professions | 8 | 1% |
| Other | 48 | 8% |
| Unknown | 80 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 218. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2023.
All research outputs
#180,205
of 25,837,817 outputs
Outputs from Cell
#1,011
of 17,278 outputs
Outputs of similar age
#1,855
of 372,766 outputs
Outputs of similar age from Cell
#17
of 146 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
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