| Title |
Leptin Mediates the Increase in Blood Pressure Associated with Obesity
|
|---|---|
| Published in |
Cell, December 2014
|
| DOI | 10.1016/j.cell.2014.10.058 |
| Pubmed ID | |
| Authors |
Stephanie E. Simonds, Jack T. Pryor, Eric Ravussin, Frank L. Greenway, Ralph Dileone, Andrew M. Allen, Jaspreet Bassi, Joel K. Elmquist, Julia M. Keogh, Elana Henning, Martin G. Myers, Julio Licinio, Russell D. Brown, Pablo J. Enriori, Stephen O’Rahilly, Scott M. Sternson, Kevin L. Grove, David C. Spanswick, I. Sadaf Farooqi, Michael A. Cowley |
| Abstract |
Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was not seen in animals deficient in leptin or leptin receptors (LepR). Furthermore, humans with loss-of-function mutations in leptin and the LepR have low BP despite severe obesity. Leptin's effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight. Re-expression of LepRs in the DMH of DIO LepR-deficient mice caused an increase in BP. These studies demonstrate that leptin couples changes in weight to changes in BP in mammalian species. |
X Demographics
The data shown below were collected from the profiles of 109 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | 18% |
| Spain | 14 | 13% |
| United Kingdom | 12 | 11% |
| Australia | 6 | 6% |
| Canada | 5 | 5% |
| Mexico | 4 | 4% |
| Venezuela, Bolivarian Republic of | 3 | 3% |
| France | 3 | 3% |
| Monaco | 1 | <1% |
| Other | 9 | 8% |
| Unknown | 32 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 72 | 66% |
| Scientists | 19 | 17% |
| Practitioners (doctors, other healthcare professionals) | 16 | 15% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 344 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| United States | 2 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| India | 1 | <1% |
| Germany | 1 | <1% |
| China | 1 | <1% |
| Netherlands | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 331 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 69 | 20% |
| Student > Ph. D. Student | 59 | 17% |
| Student > Bachelor | 34 | 10% |
| Student > Master | 32 | 9% |
| Other | 18 | 5% |
| Other | 70 | 20% |
| Unknown | 62 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 87 | 25% |
| Medicine and Dentistry | 61 | 18% |
| Biochemistry, Genetics and Molecular Biology | 51 | 15% |
| Neuroscience | 25 | 7% |
| Nursing and Health Professions | 8 | 2% |
| Other | 35 | 10% |
| Unknown | 77 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 227. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2018.
All research outputs
#168,530
of 25,459,177 outputs
Outputs from Cell
#945
of 17,195 outputs
Outputs of similar age
#1,716
of 369,479 outputs
Outputs of similar age from Cell
#15
of 146 outputs
Altmetric has tracked 25,459,177 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,195 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.2. This one has done particularly well, scoring higher than 94% of its peers.
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