| Title |
BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A
|
|---|---|
| Published in |
Cell Reports, August 2015
|
| DOI | 10.1016/j.celrep.2015.07.038 |
| Pubmed ID | |
| Authors |
David Lau, C. Peter Bengtson, Bettina Buchthal, Hilmar Bading |
| Abstract |
The health of neurons is critically dependent on the relative signaling intensities of survival-promoting synaptic and death-inducing extrasynaptic NMDA receptors. Here, we show that BDNF is a regulator of this balance and promotes neuroprotection by reducing toxic NMDA receptor signaling. BDNF acts by initiating synaptic NMDA-receptor/nuclear-calcium-driven adaptogenomics, leading to increased expression of inhibin β-A (inhba). Inhibin β-A (its homodimer is known as activin A) in turn reduces neurotoxic extrasynaptic NMDA-receptor-mediated calcium influx, thereby shielding neurons against mitochondrial dysfunction, a major cause of excitotoxicity. Thus, BDNF induces acquired neuroprotection by enhancing synaptic activity and lowering extrasynaptic NMDA receptor death signaling through a nuclear calcium-inhibin β-A pathway. This process, which confers protection against ischemic brain damage in a mouse stroke model, may be compromised in Huntington's disease, Alzheimer's disease, or aging-related neurodegenerative conditions that are associated with reduced BDNF levels and/or enhanced extrasynaptic NMDA receptor signaling. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 30% |
| United Kingdom | 2 | 20% |
| Brazil | 1 | 10% |
| Japan | 1 | 10% |
| Unknown | 3 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 70% |
| Scientists | 2 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Israel | 1 | <1% |
| Colombia | 1 | <1% |
| Unknown | 130 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 18% |
| Researcher | 22 | 17% |
| Student > Bachelor | 21 | 16% |
| Student > Master | 20 | 15% |
| Other | 9 | 7% |
| Other | 12 | 9% |
| Unknown | 25 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 39 | 29% |
| Agricultural and Biological Sciences | 21 | 16% |
| Medicine and Dentistry | 17 | 13% |
| Biochemistry, Genetics and Molecular Biology | 13 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Other | 8 | 6% |
| Unknown | 28 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2018.
All research outputs
#569,464
of 25,373,627 outputs
Outputs from Cell Reports
#1,193
of 12,956 outputs
Outputs of similar age
#6,856
of 276,161 outputs
Outputs of similar age from Cell Reports
#19
of 204 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,956 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one has done particularly well, scoring higher than 90% of its peers.
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We're also able to compare this research output to 204 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.