| Title |
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
|
|---|---|
| Published in |
Cell, May 2013
|
| DOI | 10.1016/j.cell.2013.04.015 |
| Pubmed ID | |
| Authors |
Francesco S. Loffredo, Matthew L. Steinhauser, Steven M. Jay, Joseph Gannon, James R. Pancoast, Pratyusha Yalamanchi, Manisha Sinha, Claudia Dall’Osso, Danika Khong, Jennifer L. Shadrach, Christine M. Miller, Britta S. Singer, Alex Stewart, Nikolaos Psychogios, Robert E. Gerszten, Adam J. Hartigan, Mi-Jeong Kim, Thomas Serwold, Amy J. Wagers, Richard T. Lee |
| Abstract |
The most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac hypertrophy in aging, we tested the influence of circulating factors using heterochronic parabiosis, a surgical technique in which joining of animals of different ages leads to a shared circulation. After 4 weeks of exposure to the circulation of young mice, cardiac hypertrophy in old mice dramatically regressed, accompanied by reduced cardiomyocyte size and molecular remodeling. Reversal of age-related hypertrophy was not attributable to hemodynamic or behavioral effects of parabiosis, implicating a blood-borne factor. Using modified aptamer-based proteomics, we identified the TGF-β superfamily member GDF11 as a circulating factor in young mice that declines with age. Treatment of old mice to restore GDF11 to youthful levels recapitulated the effects of parabiosis and reversed age-related hypertrophy, revealing a therapeutic opportunity for cardiac aging. |
X Demographics
The data shown below were collected from the profiles of 110 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 28 | 25% |
| United Kingdom | 9 | 8% |
| Australia | 5 | 5% |
| Mexico | 3 | 3% |
| Brazil | 3 | 3% |
| Japan | 3 | 3% |
| Sweden | 2 | 2% |
| Germany | 2 | 2% |
| France | 2 | 2% |
| Other | 11 | 10% |
| Unknown | 42 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 84 | 76% |
| Scientists | 20 | 18% |
| Practitioners (doctors, other healthcare professionals) | 3 | 3% |
| Science communicators (journalists, bloggers, editors) | 3 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,065 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 33 | 3% |
| United Kingdom | 7 | <1% |
| Japan | 5 | <1% |
| Portugal | 4 | <1% |
| Spain | 3 | <1% |
| Germany | 3 | <1% |
| Korea, Republic of | 2 | <1% |
| Italy | 2 | <1% |
| Netherlands | 2 | <1% |
| Other | 17 | 2% |
| Unknown | 987 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 238 | 22% |
| Researcher | 238 | 22% |
| Student > Bachelor | 100 | 9% |
| Student > Master | 94 | 9% |
| Professor > Associate Professor | 50 | 5% |
| Other | 207 | 19% |
| Unknown | 138 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 336 | 32% |
| Biochemistry, Genetics and Molecular Biology | 221 | 21% |
| Medicine and Dentistry | 163 | 15% |
| Engineering | 40 | 4% |
| Neuroscience | 35 | 3% |
| Other | 100 | 9% |
| Unknown | 170 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1047. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2024.
All research outputs
#15,224
of 25,703,943 outputs
Outputs from Cell
#121
of 17,261 outputs
Outputs of similar age
#57
of 205,150 outputs
Outputs of similar age from Cell
#3
of 127 outputs
Altmetric has tracked 25,703,943 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,261 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.6. This one has done particularly well, scoring higher than 99% of its peers.
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