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Vaccines for preventing infection with Pseudomonas aeruginosa in cystic fibrosis

Overview of attention for article published in Cochrane database of systematic reviews, August 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)

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139 Mendeley
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Title
Vaccines for preventing infection with Pseudomonas aeruginosa in cystic fibrosis
Published in
Cochrane database of systematic reviews, August 2015
DOI 10.1002/14651858.cd001399.pub4
Pubmed ID
Authors

Helle Krogh Johansen, Peter C Gøtzsche

Abstract

Chronic pulmonary infection in cystic fibrosis results in progressive lung damage. Once colonisation of the lungs with Pseudomonas aeruginosa occurs, it is almost impossible to eradicate. Vaccines, aimed at reducing infection with Pseudomonas aeruginosa, have been developed. This is an update of a previously published review. To assess the effectiveness of vaccination against Pseudomonas aeruginosa in cystic fibrosis. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register using the terms vaccines AND pseudomonas (last search 30 March 2015). We previously searched PubMed using the terms vaccin* AND cystic fibrosis (last search 30 May 2013). Randomised trials (published or unpublished) comparing Pseudomonas aeruginosa vaccines (oral, parenteral or intranasal) with control vaccines or no intervention in cystic fibrosis. The authors independently selected trials, assessed them and extracted data. Six trials were identified. Two trials were excluded since they were not randomised and one old, small trial because it was not possible to assess whether is was randomised. The three included trials comprised 483, 476 and 37 patients, respectively. No data have been published from one of the large trials, but the company stated in a press release that the trial failed to confirm the results from an earlier study and that further clinical development was suspended. In the other large trial, relative risk for chronic infection was 0.91 (95% confidence interval 0.55 to 1.49), and in the small trial, the risk was also close to one. In the large trial, one patient was reported to have died in the observation period. In that trial, 227 adverse events (4 severe) were registered in the vaccine group and 91 (1 severe) in the control group. In this large trial of a vaccine developed against flagella antigens, antibody titres against the epitopes contained in the vaccine were higher in the vaccine group compared to the placebo group (P < 0.0001). Vaccines against Pseudomonas aeruginosa cannot be recommended.

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X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 139 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 <1%
Canada 1 <1%
Unknown 137 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 22 16%
Student > Ph. D. Student 18 13%
Student > Bachelor 18 13%
Researcher 15 11%
Other 6 4%
Other 22 16%
Unknown 38 27%
Readers by discipline Count As %
Medicine and Dentistry 27 19%
Agricultural and Biological Sciences 18 13%
Immunology and Microbiology 14 10%
Biochemistry, Genetics and Molecular Biology 11 8%
Pharmacology, Toxicology and Pharmaceutical Science 8 6%
Other 20 14%
Unknown 41 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2017.
All research outputs
#14,334,632
of 25,457,297 outputs
Outputs from Cochrane database of systematic reviews
#9,764
of 11,499 outputs
Outputs of similar age
#124,432
of 277,911 outputs
Outputs of similar age from Cochrane database of systematic reviews
#220
of 268 outputs
Altmetric has tracked 25,457,297 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,499 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.0. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,911 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 268 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.