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Oestrogens and progestins for preventing and treating postpartum depression

Overview of attention for article published in Cochrane database of systematic reviews, January 2000
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Title
Oestrogens and progestins for preventing and treating postpartum depression
Published in
Cochrane database of systematic reviews, January 2000
DOI 10.1002/14651858.cd001690
Pubmed ID
Authors

Lawrie, T A, Herxheimer, A, Dalton, K

Abstract

Postnatal depression, with a prevalence of at least 10%, is probably the most common complication of the puerperium. A deficiency or imbalance of sex hormones has repeatedly been suggested as a cause. The objective of this review was to evaluate the role of oestrogens and progestogens in the prevention and treatment of postnatal depression. The register of clinical trials maintained and updated by the Cochrane Pregnancy and Childbirth Group. All trials were considered in which pregnant or postpartum women (up to 18 months) were randomised to receive postpartum oestrogen or progestogen or placebo for the treatment or prevention of postnatal depression. Two published randomised placebo controlled trials were identified for inclusion in the analyses for this review. One study was excluded. Depot norethisterone enanthate given within 48 hours of delivery and lasting 8-12 weeks was associated with significantly higher postpartum depression scores than placebo. Oestrogen therapy in severely depressed women was associated with a greater improvement in depression scores than placebo. There is no place for synthetic progestogens in the prevention of treatment of postnatal depression. Long-acting norethisterone enanthate is associated with an increased risk of postnatal depression. It and other long-acting progestogen contraceptives should be used with caution in the postnatal period, especially in women with a history of depression. The role of progesterone in the prevention and treatment of postnatal depression has yet to be evaluated in a randomised placebo-controlled trial. Oestrogen therapy may be of modest value at a late stage of severe postnatal depression. Its role in the prevention of recurrent postnatal depression has not been evaluated. Further research on its value is unlikely for ethical reasons.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 24%
Researcher 7 17%
Student > Bachelor 6 14%
Student > Ph. D. Student 6 14%
Lecturer 2 5%
Other 1 2%
Unknown 10 24%
Readers by discipline Count As %
Psychology 14 33%
Medicine and Dentistry 6 14%
Neuroscience 5 12%
Agricultural and Biological Sciences 2 5%
Nursing and Health Professions 1 2%
Other 4 10%
Unknown 10 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#15,380,359
of 22,881,154 outputs
Outputs from Cochrane database of systematic reviews
#10,796
of 12,329 outputs
Outputs of similar age
#90,399
of 107,878 outputs
Outputs of similar age from Cochrane database of systematic reviews
#22
of 35 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,329 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.5. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,878 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.