Title |
Pioglitazone for type 2 diabetes mellitus
|
---|---|
Published in |
Cochrane database of systematic reviews, October 2006
|
DOI | 10.1002/14651858.cd006060.pub2 |
Pubmed ID | |
Authors |
Bernd Richter, Elizabeth Bandeira‐Echtler, Karla Bergerhoff, Christine Clar, Susanne H Ebrahim |
Abstract |
Diabetes has long been recognised as a strong, independent risk factor for cardiovascular disease, a problem which accounts for approximately 70% of all mortality in people with diabetes. Prospective studies show that compared to their non-diabetic counterparts, the relative risk of cardiovascular mortality for men with diabetes is two to three and for women with diabetes is three to four. The two biggest trials in type 2 diabetes, the United Kingdom Prospective Diabetes Study (UKPDS) and the University Group Diabetes Program (UGDP) study did not reveal a reduction of cardiovascular endpoints through improved metabolic control. Theoretical benefits of the newer peroxisome proliferator activated receptor gamma (PPAR-gamma) activators like pioglitazone on endothelial function and cardiovascular risk factors might result in fewer macrovascular disease events in people with type 2 diabetes mellitus. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 2 | 67% |
Thailand | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 5 | 2% |
Italy | 2 | <1% |
Canada | 2 | <1% |
Spain | 2 | <1% |
United Kingdom | 1 | <1% |
Ireland | 1 | <1% |
South Africa | 1 | <1% |
Japan | 1 | <1% |
Unknown | 288 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 57 | 19% |
Student > Bachelor | 37 | 12% |
Researcher | 36 | 12% |
Student > Ph. D. Student | 25 | 8% |
Student > Doctoral Student | 14 | 5% |
Other | 62 | 20% |
Unknown | 72 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 116 | 38% |
Nursing and Health Professions | 31 | 10% |
Psychology | 12 | 4% |
Agricultural and Biological Sciences | 10 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 3% |
Other | 39 | 13% |
Unknown | 86 | 28% |