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Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease

Overview of attention for article published in this source, March 2013
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Title
Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease
Published by
John Wiley & Sons, Ltd, March 2013
DOI 10.1002/14651858.cd009191.pub2
Pubmed ID
Authors

Sasongko, Teguh H, Nagalla, Srikanth, Ballas, Samir K

Abstract

Sickle cell disease is a group of disorders characterized by deformation of erythrocytes. Renal damage is a frequent complication in sickle cell disease as a result of long-standing anemia and disturbed circulation through the renal medullary capillaries. Due to the improvement in life expectancy of people with sickle cell disease, there has been a corresponding significant increase in the incidence of renal complications. Microalbuminuria and proteinuria are noted to be a strong predictor of subsequent renal failure. There is extensive experience and evidence with angiotensin-converting enzyme (ACE) inhibitors over many years in a variety of clinical situations for patients who do not have sickle cell disease, but their effect in patients with this disease is unknown. It is common practice to administer ACE inhibitors for sickle nephropathy due to their renoprotective properties; however, little is known about their effectiveness and safety in this setting.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 16%
Student > Master 6 16%
Student > Ph. D. Student 5 13%
Other 5 13%
Student > Postgraduate 3 8%
Other 6 16%
Unknown 7 18%
Readers by discipline Count As %
Medicine and Dentistry 15 39%
Biochemistry, Genetics and Molecular Biology 4 11%
Nursing and Health Professions 3 8%
Social Sciences 2 5%
Environmental Science 1 3%
Other 2 5%
Unknown 11 29%