Title |
Extracorporeal photopheresis versus alternative treatment for chronic graft-versus-host disease after haematopoietic stem cell transplantation in paediatric patients.
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Published in |
Cochrane database of systematic reviews, February 2014
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DOI | 10.1002/14651858.cd009898.pub2 |
Pubmed ID | |
Authors |
Weitz M, Strahm B, Meerpohl JJ, Bassler D, Weitz, Marcus, Strahm, Brigitte, Meerpohl, Joerg J, Bassler, Dirk |
Abstract |
Chronic graft-versus-host disease (GvHD) is a major cause of morbidity and mortality after haematopoietic stem cell transplantation occurring in 6% to 65% of the recipients. Currently, the therapeutic mainstay for chronic GvHD are corticosteroids that are frequently combined with other immunosuppressive agents in people with steroid-refractory manifestations. There is no established standard treatment for steroid-refractory chronic GvHD. The therapeutic options in these people include extracorporeal photopheresis (ECP), an immunomodulatory treatment that involves ex vivo collection of mononuclear cells from peripheral blood, exposure to the photoactive agent 8-methoxypsoralen, ultraviolet radiation and re-infusion of the processed cell product. The mechanisms of action of ECP are not completely understood. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 24% |
Student > Master | 4 | 16% |
Student > Ph. D. Student | 3 | 12% |
Student > Postgraduate | 3 | 12% |
Professor > Associate Professor | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 36% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Agricultural and Biological Sciences | 2 | 8% |
Economics, Econometrics and Finance | 1 | 4% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Other | 2 | 8% |
Unknown | 8 | 32% |