| Title |
Early amniocentesis versus transabdominal chorion villus sampling for prenatal diagnosis
|
|---|---|
| Published in |
Cochrane database of systematic reviews, January 1999
|
| DOI | 10.1002/14651858.cd000077 |
| Pubmed ID | |
| Authors |
Zarko Alfirevic |
| Abstract |
A major disadvantage of amniocentesis is that test results are usually available only after 18 weeks gestation. Early amniocentesis can now be done between 9 to 14 weeks gestation. The objective was to assess the safety and accuracy of early amniocentesis compared with chorion villus sampling. The Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register were searched. Date of last search: October 1998. Randomised trials comparing early amniocentesis with transabdominal chorion villus sampling. One reviewer assessed eligibility and trial quality. Three studies were included. Sampling failure was 0.4% in the early amniocentesis group compared to 2% in the chorion villus group (relative risk 0.23, 95% confidence interval 0.08 to 0.65). Consequently, more women in the chorion villus sampling group needed a second prenatal diagnostic test (relative risk 0.43, 95% confidence interval 0.21 to 0.88). There were no statistically significant differences in the laboratory failures (relative risk 0.43, 95% confidence interval 0. 17 to 1.10) or number of women with various chromosomal abnormalities (relative risk 0.51, 95% confidence interval 0.26 to 1. 04). Combined total pregnancy loss in the early amniocentesis group was 6.2% (57/915) compared with 5% (46/917) in the chorion villus sampling group (relative risk 1.24, 95% confidence interval 0.85 to 1.81). There were more spontaneous miscarriages after early amniocentesis (4.4% versus 2.3%, relative risk 1.92, 95% confidence interval 1.14 to 3.23). There was no difference in the incidence of neonatal respiratory distress and anomalies in the newborn infants. The incidence of talipes was greater in the early amniocentesis group, although haemangiomas were more common in the chorion villus sampling group. Current data suggest that early amniocentesis is associated with a greater risk of spontaneous miscarriage and neonatal talipes compared to transabdominal chorion villus sampling. An increased risk of these complications needs to be weighed against fewer technical difficulties and the possibility of fewer neonatal haemangiomas. |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 3% |
| Unknown | 33 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 6 | 18% |
| Student > Ph. D. Student | 4 | 12% |
| Other | 3 | 9% |
| Librarian | 2 | 6% |
| Student > Doctoral Student | 2 | 6% |
| Other | 12 | 35% |
| Unknown | 5 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 32% |
| Unspecified | 6 | 18% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Linguistics | 2 | 6% |
| Psychology | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 8 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2019.
All research outputs
#7,531,972
of 22,982,639 outputs
Outputs from Cochrane database of systematic reviews
#9,005
of 12,337 outputs
Outputs of similar age
#21,929
of 98,861 outputs
Outputs of similar age from Cochrane database of systematic reviews
#7
of 12 outputs
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