Title |
Interferon for interferon nonresponding and relapsing patients with chronic hepatitis C
|
---|---|
Published in |
Cochrane database of systematic reviews, January 2013
|
DOI | 10.1002/14651858.cd003617.pub2 |
Pubmed ID | |
Authors |
Ronald L Koretz, Maria Pleguezuelo, Vasiliki Arvaniti, Pilar Barrera Baena, Ruben Ciria, Kurinchi Selvan Gurusamy, Brian R Davidson, Andrew K Burroughs |
Abstract |
The widely-accepted treatment outcome for chronic hepatitis C is the sustained viral response (that is, no measurable viral RNA in blood six months after treatment). However, this surrogate outcome (as well as the previously employed biochemical and histologic ones) has never been validated. This situation exists because there are very few randomized clinical trials that have used clinical events (mortality or manifestations of decompensated cirrhosis) as outcomes, because those clinical events only occur after many years of infection. Patients in whom initial therapy fails to produce sustained viral responses do become potential candidates for retreatment; some of these individuals are not candidates for ribavirin or protease inhibitors and consideration could be given to retreatment with interferon alone. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 36% |
Brazil | 1 | 9% |
India | 1 | 9% |
Spain | 1 | 9% |
Unknown | 4 | 36% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 82% |
Science communicators (journalists, bloggers, editors) | 1 | 9% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 151 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 26 | 17% |
Researcher | 20 | 13% |
Student > Bachelor | 18 | 12% |
Student > Ph. D. Student | 14 | 9% |
Other | 13 | 8% |
Other | 34 | 22% |
Unknown | 30 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 72 | 46% |
Nursing and Health Professions | 13 | 8% |
Psychology | 5 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Social Sciences | 4 | 3% |
Other | 18 | 12% |
Unknown | 38 | 25% |