Title |
Postoperative adjuvant chemotherapy in rectal cancer operated for cure.
|
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Published in |
Cochrane database of systematic reviews, March 2012
|
DOI | 10.1002/14651858.cd004078.pub2 |
Pubmed ID | |
Authors |
Sune Høirup Petersen, Henrik Harling, Lene Tschemerinsky Kirkeby, Peer Wille‐Jørgensen, Simone Mocellin |
Abstract |
Colorectal cancer is one of the most common types of cancer in the Western world. Apart from surgery - which remains the mainstay of treatment for resectable primary tumours - postoperative (i.e., adjuvant) chemotherapy with 5-fluorouracil (5-FU) based regimens is now the standard treatment in Dukes' C (TNM stage III) colon tumours i.e. tumours with metastases in the regional lymph nodes but no distant metastases. In contrast, the evidence for recommendations of adjuvant therapy in rectal cancer is sparse. In Europe it is generally acknowledged that locally advanced rectal tumours receive preoperative (i.e., neoadjuvant) downstaging by radiotherapy (or chemoradiotion), whereas in the US postoperative chemoradiotion is considered the treatment of choice in all Dukes' C rectal cancers. Overall, no universal consensus exists on the adjuvant treatment of surgically resectable rectal carcinoma; moreover, no formal systematic review and meta-analysis has been so far performed on this subject. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 60% |
Brazil | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Ecuador | 2 | <1% |
Spain | 2 | <1% |
Iran, Islamic Republic of | 1 | <1% |
France | 1 | <1% |
Estonia | 1 | <1% |
United States | 1 | <1% |
Unknown | 255 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 44 | 17% |
Other | 30 | 11% |
Student > Ph. D. Student | 29 | 11% |
Student > Master | 28 | 11% |
Student > Bachelor | 20 | 8% |
Other | 51 | 19% |
Unknown | 61 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 145 | 55% |
Nursing and Health Professions | 13 | 5% |
Agricultural and Biological Sciences | 9 | 3% |
Biochemistry, Genetics and Molecular Biology | 5 | 2% |
Social Sciences | 4 | 2% |
Other | 13 | 5% |
Unknown | 74 | 28% |