Title |
Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease
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Published by |
John Wiley & Sons, Ltd, March 2013
|
DOI | 10.1002/14651858.cd009191.pub2 |
Pubmed ID | |
Authors |
Sasongko, Teguh H, Nagalla, Srikanth, Ballas, Samir K |
Abstract |
Sickle cell disease is a group of disorders characterized by deformation of erythrocytes. Renal damage is a frequent complication in sickle cell disease as a result of long-standing anemia and disturbed circulation through the renal medullary capillaries. Due to the improvement in life expectancy of people with sickle cell disease, there has been a corresponding significant increase in the incidence of renal complications. Microalbuminuria and proteinuria are noted to be a strong predictor of subsequent renal failure. There is extensive experience and evidence with angiotensin-converting enzyme (ACE) inhibitors over many years in a variety of clinical situations for patients who do not have sickle cell disease, but their effect in patients with this disease is unknown. It is common practice to administer ACE inhibitors for sickle nephropathy due to their renoprotective properties; however, little is known about their effectiveness and safety in this setting. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 25% |
Australia | 1 | 25% |
France | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 16% |
Student > Master | 6 | 16% |
Student > Ph. D. Student | 5 | 13% |
Other | 5 | 13% |
Student > Postgraduate | 3 | 8% |
Other | 6 | 16% |
Unknown | 7 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 39% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Nursing and Health Professions | 3 | 8% |
Social Sciences | 2 | 5% |
Environmental Science | 1 | 3% |
Other | 2 | 5% |
Unknown | 11 | 29% |