Title |
Mycophenolate mofetil versus methotrexate for prevention of graft‐versus‐host disease in people receiving allogeneic hematopoietic stem cell transplantation
|
---|---|
Published in |
Cochrane database of systematic reviews, July 2014
|
DOI | 10.1002/14651858.cd010280.pub2 |
Pubmed ID | |
Authors |
Mohamed Kharfan‐Dabaja, Rahul Mhaskar, Tea Reljic, Joseph Pidala, Janelle B Perkins, Benjamin Djulbegovic, Ambuj Kumar |
Abstract |
Allogeneic hematopoietic stem cell transplantation (allo-HCT) is associated with improved outcomes for people with various hematologic diseases; however, the morbidity and mortality resulting from acute and subsequently chronic graft-versus-host disease (GVHD) pose a serious challenge to wider applicability of allo-HCT. Intravenous methotrexate in combination with a calcineurin inhibitor, cyclosporine or tacrolimus, is a widely used regimen for the prophylaxis of acute GVHD, but the administration of methotrexate is associated with a number of adverse events. Mycophenolate mofetil, in combination with a calcineurin inhibitor, has been used extensively in people undergoing allo-HCT. Conflicting results regarding various clinical outcomes following allo-HCT have been observed when comparing mycophenolate mofetil-based regimens against methotrexate-based regimens for acute GVHD prophylaxis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 17% |
Unknown | 5 | 83% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 2 | 33% |
Members of the public | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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South Africa | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 168 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 27 | 16% |
Student > Ph. D. Student | 17 | 10% |
Student > Bachelor | 17 | 10% |
Researcher | 15 | 9% |
Student > Postgraduate | 14 | 8% |
Other | 29 | 17% |
Unknown | 51 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 64 | 38% |
Nursing and Health Professions | 11 | 6% |
Biochemistry, Genetics and Molecular Biology | 8 | 5% |
Psychology | 7 | 4% |
Social Sciences | 7 | 4% |
Other | 16 | 9% |
Unknown | 57 | 34% |