Title |
Successful treatment of avian-origin influenza A (H7N9) infection using convalescent plasma
|
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Published in |
International Journal of Infectious Diseases, October 2015
|
DOI | 10.1016/j.ijid.2015.10.009 |
Pubmed ID | |
Authors |
Xiao-Xin Wu, Hai-Nv Gao, Hai-Bo Wu, Xiu-Ming Peng, Hui-Lin Ou, Lan-Juan Li |
Abstract |
In January 2015, there was an outbreak of avian-origin influenza A (H7N9) virus in Zhejiang province, China. A 45-year-old man was admitted to the First Affiliated Hospital of Zhejiang University with a high fever that had lasted 7-days, chills, and a cough with yellow sputum. Laboratory testing confirmed infection with the H7N9 virus, likely obtained from contact with poultry at a local live poultry market. A large dense shadow was apparent in the patient's left lung at the time of admission. Treatment with oseltamivir (75mg twice daily) did not improve the patient's condition. The decision was made to try using convalescent plasma to treat the infection. Convalescent plasma was administered three days after the patient was admitted to the hospital and led to marked improvement. To our knowledge, this is the first case to report successfully using convalescent plasma to treat an H7N9 infection in China. Our results suggest that the combination of convalescent plasma and antiviral drugs may be effective for treating avian-origin H7N9 infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 25% |
India | 1 | 25% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 19% |
Student > Master | 6 | 10% |
Student > Bachelor | 6 | 10% |
Other | 5 | 9% |
Student > Doctoral Student | 4 | 7% |
Other | 13 | 22% |
Unknown | 13 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 34% |
Immunology and Microbiology | 6 | 10% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Agricultural and Biological Sciences | 2 | 3% |
Other | 5 | 9% |
Unknown | 18 | 31% |