| Title |
Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly
|
|---|---|
| Published in |
Nature Chemistry, September 2013
|
| DOI | 10.1038/nchem.1745 |
| Pubmed ID | |
| Authors |
Thomas G. W. Edwardson, Karina M. M. Carneiro, Christopher K. McLaughlin, Christopher J. Serpell, Hanadi F. Sleiman |
| Abstract |
Nature uses a combination of non-covalent interactions to create a hierarchy of complex systems from simple building blocks. One example is the selective association of the hydrophobic side chains that are a strong determinant of protein organization. Here, we report a parallel mode of assembly in DNA nanotechnology. Dendritic alkyl-DNA conjugates are hybridized to the edges of a DNA cube. When four amphiphiles are on one face, the hydrophobic residues of two neighbouring cubes engage in an intermolecular 'handshake', resulting in a dimer. When there are eight amphiphiles (four on the top and bottom cube faces, respectively), they engage in an intramolecular 'handshake' inside the cube. This forms the first example of a monodisperse micelle within a DNA nanostructure that encapsulates small molecules and releases them by DNA recognition. Creating a three-dimensional pattern of hydrophobic patches, like side chains in proteins, can result in specific, directed association of hydrophobic domains with orthogonal interactions to DNA base-pairing. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 20% |
| United Kingdom | 2 | 20% |
| South Africa | 1 | 10% |
| Syrian Arab Republic | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 40% |
| Scientists | 4 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 2% |
| Netherlands | 1 | <1% |
| India | 1 | <1% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| Belgium | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| United States | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 176 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 51 | 27% |
| Researcher | 36 | 19% |
| Student > Master | 23 | 12% |
| Student > Bachelor | 17 | 9% |
| Student > Doctoral Student | 12 | 6% |
| Other | 27 | 14% |
| Unknown | 22 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 80 | 43% |
| Biochemistry, Genetics and Molecular Biology | 27 | 14% |
| Agricultural and Biological Sciences | 22 | 12% |
| Materials Science | 9 | 5% |
| Engineering | 8 | 4% |
| Other | 16 | 9% |
| Unknown | 26 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 107. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2023.
All research outputs
#337,485
of 23,151,189 outputs
Outputs from Nature Chemistry
#205
of 3,035 outputs
Outputs of similar age
#2,691
of 201,178 outputs
Outputs of similar age from Nature Chemistry
#2
of 46 outputs
Altmetric has tracked 23,151,189 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,035 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.