| Title |
Neural compensation in older people with brain amyloid-β deposition
|
|---|---|
| Published in |
Nature Neuroscience, September 2014
|
| DOI | 10.1038/nn.3806 |
| Pubmed ID | |
| Authors |
Jeremy A Elman, Hwamee Oh, Cindee M Madison, Suzanne L Baker, Jacob W Vogel, Shawn M Marks, Sam Crowley, James P O'Neil, William J Jagust |
| Abstract |
Recruitment of extra neural resources may allow people to maintain normal cognition despite amyloid-β (Aβ) plaques. Previous fMRI studies have reported such hyperactivation, but it is unclear whether increases represent compensation or aberrant overexcitation. We found that older adults with Aβ deposition had reduced deactivations in task-negative regions, but increased activation in task-positive regions related to more detailed memory encoding. The association between higher activity and more detailed memories suggests that Aβ-related hyperactivation is compensatory. |
X Demographics
The data shown below were collected from the profiles of 35 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 9 | 26% |
| United States | 8 | 23% |
| Italy | 2 | 6% |
| Spain | 2 | 6% |
| Japan | 2 | 6% |
| France | 1 | 3% |
| Sweden | 1 | 3% |
| India | 1 | 3% |
| Mexico | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 7 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 26 | 74% |
| Scientists | 4 | 11% |
| Science communicators (journalists, bloggers, editors) | 3 | 9% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 286 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| Italy | 2 | <1% |
| Spain | 2 | <1% |
| Chile | 1 | <1% |
| Turkey | 1 | <1% |
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Sweden | 1 | <1% |
| China | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 270 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 71 | 25% |
| Researcher | 56 | 20% |
| Student > Master | 31 | 11% |
| Student > Bachelor | 31 | 11% |
| Student > Postgraduate | 16 | 6% |
| Other | 48 | 17% |
| Unknown | 33 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 62 | 22% |
| Agricultural and Biological Sciences | 49 | 17% |
| Psychology | 43 | 15% |
| Medicine and Dentistry | 38 | 13% |
| Biochemistry, Genetics and Molecular Biology | 14 | 5% |
| Other | 22 | 8% |
| Unknown | 58 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 174. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2014.
All research outputs
#209,440
of 23,932,398 outputs
Outputs from Nature Neuroscience
#356
of 5,368 outputs
Outputs of similar age
#1,912
of 249,040 outputs
Outputs of similar age from Nature Neuroscience
#6
of 78 outputs
Altmetric has tracked 23,932,398 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,368 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,040 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.