| Title |
Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury
|
|---|---|
| Published in |
Nature, December 2014
|
| DOI | 10.1038/nature13974 |
| Pubmed ID | |
| Authors |
Bradley T. Lang, Jared M. Cregg, Marc A. DePaul, Amanda P. Tran, Kui Xu, Scott M. Dyck, Kathryn M. Madalena, Benjamin P. Brown, Yi-Lan Weng, Shuxin Li, Soheila Karimi-Abdolrezaee, Sarah A. Busch, Yingjie Shen, Jerry Silver |
| Abstract |
Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal regeneration and functional plasticity. It is well established that an upregulation of glial-derived chondroitin sulphate proteoglycans (CSPGs) within the glial scar and perineuronal net creates a barrier to axonal regrowth and sprouting. Protein tyrosine phosphatase σ (PTPσ), along with its sister phosphatase leukocyte common antigen-related (LAR) and the nogo receptors 1 and 3 (NgR), have recently been identified as receptors for the inhibitory glycosylated side chains of CSPGs. Here we find in rats that PTPσ has a critical role in converting growth cones into a dystrophic state by tightly stabilizing them within CSPG-rich substrates. We generated a membrane-permeable peptide mimetic of the PTPσ wedge domain that binds to PTPσ and relieves CSPG-mediated inhibition. Systemic delivery of this peptide over weeks restored substantial serotonergic innervation to the spinal cord below the level of injury and facilitated functional recovery of both locomotor and urinary systems. Our results add a new layer of understanding to the critical role of PTPσ in mediating the growth-inhibited state of neurons due to CSPGs within the injured adult spinal cord. |
X Demographics
The data shown below were collected from the profiles of 70 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 20% |
| Australia | 8 | 11% |
| United Kingdom | 6 | 9% |
| Spain | 5 | 7% |
| India | 2 | 3% |
| Turkey | 2 | 3% |
| Germany | 1 | 1% |
| Canada | 1 | 1% |
| Brazil | 1 | 1% |
| Other | 7 | 10% |
| Unknown | 23 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 49 | 70% |
| Scientists | 11 | 16% |
| Practitioners (doctors, other healthcare professionals) | 7 | 10% |
| Science communicators (journalists, bloggers, editors) | 3 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 405 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 1% |
| Germany | 2 | <1% |
| Canada | 2 | <1% |
| China | 2 | <1% |
| United Kingdom | 2 | <1% |
| Chile | 1 | <1% |
| France | 1 | <1% |
| Colombia | 1 | <1% |
| Ireland | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 388 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 83 | 20% |
| Researcher | 72 | 18% |
| Student > Bachelor | 42 | 10% |
| Student > Master | 30 | 7% |
| Student > Doctoral Student | 29 | 7% |
| Other | 71 | 18% |
| Unknown | 78 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 89 | 22% |
| Agricultural and Biological Sciences | 77 | 19% |
| Medicine and Dentistry | 51 | 13% |
| Biochemistry, Genetics and Molecular Biology | 39 | 10% |
| Engineering | 22 | 5% |
| Other | 42 | 10% |
| Unknown | 85 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 286. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2022.
All research outputs
#125,044
of 25,837,817 outputs
Outputs from Nature
#8,259
of 98,779 outputs
Outputs of similar age
#1,246
of 371,794 outputs
Outputs of similar age from Nature
#109
of 958 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
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