Title |
Transfer of molecular recognition information from DNA nanostructures to gold nanoparticles
|
---|---|
Published in |
Nature Chemistry, January 2016
|
DOI | 10.1038/nchem.2420 |
Pubmed ID | |
Authors |
Thomas G. W. Edwardson, Kai Lin Lau, Danny Bousmail, Christopher J. Serpell, Hanadi F. Sleiman |
Abstract |
DNA nanotechnology offers unparalleled precision and programmability for the bottom-up organization of materials. This approach relies on pre-assembling a DNA scaffold, typically containing hundreds of different strands, and using it to position functional components. A particularly attractive strategy is to employ DNA nanostructures not as permanent scaffolds, but as transient, reusable templates to transfer essential information to other materials. To our knowledge, this approach, akin to top-down lithography, has not been examined. Here we report a molecular printing strategy that chemically transfers a discrete pattern of DNA strands from a three-dimensional DNA structure to a gold nanoparticle. We show that the particles inherit the DNA sequence configuration encoded in the parent template with high fidelity. This provides control over the number of DNA strands and their relative placement, directionality and sequence asymmetry. Importantly, the nanoparticles produced exhibit the site-specific addressability of DNA nanostructures, and are promising components for energy, information and biomedical applications. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 10% |
United Kingdom | 2 | 10% |
Spain | 1 | 5% |
Brazil | 1 | 5% |
India | 1 | 5% |
Czechia | 1 | 5% |
Hungary | 1 | 5% |
France | 1 | 5% |
Sri Lanka | 1 | 5% |
Other | 0 | 0% |
Unknown | 9 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 14 | 70% |
Scientists | 4 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
France | 1 | <1% |
United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
Japan | 1 | <1% |
Unknown | 205 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 73 | 35% |
Researcher | 27 | 13% |
Student > Master | 23 | 11% |
Student > Bachelor | 16 | 8% |
Student > Doctoral Student | 11 | 5% |
Other | 26 | 12% |
Unknown | 34 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 91 | 43% |
Biochemistry, Genetics and Molecular Biology | 17 | 8% |
Agricultural and Biological Sciences | 14 | 7% |
Materials Science | 13 | 6% |
Engineering | 12 | 6% |
Other | 26 | 12% |
Unknown | 37 | 18% |