| Title |
The Drosophila melanogaster Genetic Reference Panel
|
|---|---|
| Published in |
Nature, February 2012
|
| DOI | 10.1038/nature10811 |
| Pubmed ID | |
| Authors |
Trudy F. C. Mackay, Stephen Richards, Eric A. Stone, Antonio Barbadilla, Julien F. Ayroles, Dianhui Zhu, Sònia Casillas, Yi Han, Michael M. Magwire, Julie M. Cridland, Mark F. Richardson, Robert R. H. Anholt, Maite Barrón, Crystal Bess, Kerstin Petra Blankenburg, Mary Anna Carbone, David Castellano, Lesley Chaboub, Laura Duncan, Zeke Harris, Mehwish Javaid, Joy Christina Jayaseelan, Shalini N. Jhangiani, Katherine W. Jordan, Fremiet Lara, Faye Lawrence, Sandra L. Lee, Pablo Librado, Raquel S. Linheiro, Richard F. Lyman, Aaron J. Mackey, Mala Munidasa, Donna Marie Muzny, Lynne Nazareth, Irene Newsham, Lora Perales, Ling-Ling Pu, Carson Qu, Miquel Ràmia, Jeffrey G. Reid, Stephanie M. Rollmann, Julio Rozas, Nehad Saada, Lavanya Turlapati, Kim C. Worley, Yuan-Qing Wu, Akihiko Yamamoto, Yiming Zhu, Casey M. Bergman, Kevin R. Thornton, David Mittelman, Richard A. Gibbs |
| Abstract |
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics. |
X Demographics
The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 18% |
| United States | 5 | 15% |
| Switzerland | 2 | 6% |
| Australia | 2 | 6% |
| Venezuela, Bolivarian Republic of | 2 | 6% |
| Spain | 1 | 3% |
| Thailand | 1 | 3% |
| Norway | 1 | 3% |
| Japan | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 10 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 58% |
| Scientists | 13 | 39% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,360 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 39 | 3% |
| United Kingdom | 8 | <1% |
| Spain | 7 | <1% |
| Netherlands | 6 | <1% |
| Germany | 5 | <1% |
| Portugal | 5 | <1% |
| Brazil | 3 | <1% |
| France | 3 | <1% |
| Canada | 3 | <1% |
| Other | 15 | 1% |
| Unknown | 1266 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 353 | 26% |
| Researcher | 278 | 20% |
| Student > Master | 156 | 11% |
| Student > Bachelor | 144 | 11% |
| Professor > Associate Professor | 66 | 5% |
| Other | 189 | 14% |
| Unknown | 174 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 713 | 52% |
| Biochemistry, Genetics and Molecular Biology | 282 | 21% |
| Neuroscience | 44 | 3% |
| Environmental Science | 13 | <1% |
| Computer Science | 13 | <1% |
| Other | 86 | 6% |
| Unknown | 209 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 50. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2023.
All research outputs
#863,605
of 25,759,158 outputs
Outputs from Nature
#29,898
of 98,680 outputs
Outputs of similar age
#5,083
of 255,825 outputs
Outputs of similar age from Nature
#321
of 939 outputs
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We're also able to compare this research output to 939 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.