| Title |
Reprogramming the assembly of unmodified DNA with a small molecule
|
|---|---|
| Published in |
Nature Chemistry, February 2016
|
| DOI | 10.1038/nchem.2451 |
| Pubmed ID | |
| Authors |
Nicole Avakyan, Andrea A. Greschner, Faisal Aldaye, Christopher J. Serpell, Violeta Toader, Anne Petitjean, Hanadi F. Sleiman |
| Abstract |
The ability of DNA to store and encode information arises from base pairing of the four-letter nucleobase code to form a double helix. Expanding this DNA 'alphabet' by synthetic incorporation of new bases can introduce new functionalities and enable the formation of novel nucleic acid structures. However, reprogramming the self-assembly of existing nucleobases presents an alternative route to expand the structural space and functionality of nucleic acids. Here we report the discovery that a small molecule, cyanuric acid, with three thymine-like faces, reprogrammes the assembly of unmodified poly(adenine) (poly(A)) into stable, long and abundant fibres with a unique internal structure. Poly(A) DNA, RNA and peptide nucleic acid (PNA) all form these assemblies. Our studies are consistent with the association of adenine and cyanuric acid units into a hexameric rosette, which brings together poly(A) triplexes with a subsequent cooperative polymerization. Fundamentally, this study shows that small hydrogen-bonding molecules can be used to induce the assembly of nucleic acids in water, which leads to new structures from inexpensive and readily available materials. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 13% |
| United Kingdom | 2 | 6% |
| Canada | 2 | 6% |
| Japan | 1 | 3% |
| Indonesia | 1 | 3% |
| Finland | 1 | 3% |
| Iran, Islamic Republic of | 1 | 3% |
| Korea, Republic of | 1 | 3% |
| Taiwan | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 17 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 63% |
| Scientists | 12 | 38% |
Mendeley readers
The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | <1% |
| Hungary | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 159 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 28% |
| Researcher | 21 | 13% |
| Student > Master | 18 | 11% |
| Student > Bachelor | 15 | 9% |
| Student > Doctoral Student | 13 | 8% |
| Other | 26 | 16% |
| Unknown | 23 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 84 | 52% |
| Biochemistry, Genetics and Molecular Biology | 13 | 8% |
| Materials Science | 11 | 7% |
| Engineering | 8 | 5% |
| Agricultural and Biological Sciences | 7 | 4% |
| Other | 13 | 8% |
| Unknown | 26 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 142. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2023.
All research outputs
#289,542
of 25,380,089 outputs
Outputs from Nature Chemistry
#131
of 3,336 outputs
Outputs of similar age
#5,056
of 312,997 outputs
Outputs of similar age from Nature Chemistry
#3
of 57 outputs
Altmetric has tracked 25,380,089 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,336 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,997 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.