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HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults

Overview of attention for article published in Journal of Infectious Diseases, December 2015
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Title
HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults
Published in
Journal of Infectious Diseases, December 2015
DOI 10.1093/infdis/jiv592
Pubmed ID
Authors

Philippa C. Matthews, Jonathan M. Carlson, Apostolos Beloukas, Amna Malik, Pieter Jooste, Anthony Ogwu, Roger Shapiro, Lynn Riddell, Fabian Chen, Graz Luzzi, Gerald Jesuthasan, Katie Jeffery, Nebojsa Jojic, Thumbi Ndung'u, Mary Carrington, Philip J. R. Goulder, Anna Maria Geretti, Paul Klenerman

Abstract

Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of HIV coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA Class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (HBeAg status / HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8+ T cell response in HBV control, and potentially informs future therapeutic T cell vaccine strategies.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 2%
Unknown 58 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 24%
Student > Ph. D. Student 11 19%
Student > Master 6 10%
Student > Doctoral Student 5 8%
Other 3 5%
Other 6 10%
Unknown 14 24%
Readers by discipline Count As %
Medicine and Dentistry 11 19%
Immunology and Microbiology 8 14%
Nursing and Health Professions 6 10%
Agricultural and Biological Sciences 6 10%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 5 8%
Unknown 20 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2016.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Journal of Infectious Diseases
#14,241
of 14,793 outputs
Outputs of similar age
#337,550
of 395,144 outputs
Outputs of similar age from Journal of Infectious Diseases
#96
of 108 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,793 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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