Title |
HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults
|
---|---|
Published in |
Journal of Infectious Diseases, December 2015
|
DOI | 10.1093/infdis/jiv592 |
Pubmed ID | |
Authors |
Philippa C. Matthews, Jonathan M. Carlson, Apostolos Beloukas, Amna Malik, Pieter Jooste, Anthony Ogwu, Roger Shapiro, Lynn Riddell, Fabian Chen, Graz Luzzi, Gerald Jesuthasan, Katie Jeffery, Nebojsa Jojic, Thumbi Ndung'u, Mary Carrington, Philip J. R. Goulder, Anna Maria Geretti, Paul Klenerman |
Abstract |
Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of HIV coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA Class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (HBeAg status / HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8+ T cell response in HBV control, and potentially informs future therapeutic T cell vaccine strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 24% |
Student > Ph. D. Student | 11 | 19% |
Student > Master | 6 | 10% |
Student > Doctoral Student | 5 | 8% |
Other | 3 | 5% |
Other | 6 | 10% |
Unknown | 14 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 19% |
Immunology and Microbiology | 8 | 14% |
Nursing and Health Professions | 6 | 10% |
Agricultural and Biological Sciences | 6 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 5 | 8% |
Unknown | 20 | 34% |