| Title |
Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing
|
|---|---|
| Published in |
Science, November 2014
|
| DOI | 10.1126/science.1259652 |
| Pubmed ID | |
| Authors |
Fabian Fernandez, Derek Lu, Phong Ha, Patricia Costacurta, Renee Chavez, H Craig Heller, Norman F Ruby |
| Abstract |
Chronic circadian dysfunction impairs declarative memory in humans but has little effect in common rodent models of arrhythmia caused by clock gene knockouts or surgical ablation of the suprachiasmatic nucleus (SCN). An important problem overlooked in these translational models is that human dysrhythmia occurs while SCN circuitry is genetically and neurologically intact. Siberian hamsters (Phodopus sungorus) are particularly well suited for translational studies because they can be made arrhythmic by a one-time photic treatment that severely impairs spatial and recognition memory. We found that once animals are made arrhythmic, subsequent SCN ablation completely rescues memory processing. These data suggest that the inhibitory effects of a malfunctioning SCN on cognition require preservation of circuitry between the SCN and downstream targets that are lost when these connections are severed. |
X Demographics
The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 18% |
| United Kingdom | 4 | 10% |
| France | 2 | 5% |
| Spain | 2 | 5% |
| Germany | 1 | 3% |
| Australia | 1 | 3% |
| Portugal | 1 | 3% |
| Canada | 1 | 3% |
| Unknown | 20 | 51% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 23 | 59% |
| Scientists | 11 | 28% |
| Science communicators (journalists, bloggers, editors) | 4 | 10% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| United States | 3 | 2% |
| Turkey | 1 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Portugal | 1 | <1% |
| Sweden | 1 | <1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 150 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 23% |
| Researcher | 35 | 21% |
| Student > Bachelor | 21 | 13% |
| Student > Master | 14 | 9% |
| Professor | 10 | 6% |
| Other | 31 | 19% |
| Unknown | 16 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 56 | 34% |
| Neuroscience | 36 | 22% |
| Medicine and Dentistry | 15 | 9% |
| Psychology | 11 | 7% |
| Biochemistry, Genetics and Molecular Biology | 8 | 5% |
| Other | 13 | 8% |
| Unknown | 25 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 122. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2019.
All research outputs
#346,690
of 25,837,817 outputs
Outputs from Science
#9,095
of 83,358 outputs
Outputs of similar age
#3,401
of 272,024 outputs
Outputs of similar age from Science
#114
of 817 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,358 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.9. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,024 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 817 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.