| Title |
An ancient defense system eliminates unfit cells from developing tissues during cell competition
|
|---|---|
| Published in |
Science, December 2014
|
| DOI | 10.1126/science.1258236 |
| Pubmed ID | |
| Authors |
S N Meyer, M Amoyel, C Bergantiños, C de la Cova, C Schertel, K Basler, L A Johnston |
| Abstract |
Developing tissues that contain mutant or compromised cells present risks to animal health. Accordingly, the appearance of a population of suboptimal cells in a tissue elicits cellular interactions that prevent their contribution to the adult. Here we report that this quality control process, cell competition, uses specific components of the evolutionarily ancient and conserved innate immune system to eliminate Drosophila cells perceived as unfit. We find that Toll-related receptors (TRRs) and the cytokine Spätzle (Spz) lead to NFκB-dependent apoptosis. Diverse "loser" cells require different TRRs and NFκB factors and activate distinct pro-death genes, implying that the particular response is stipulated by the competitive context. Our findings demonstrate a functional repurposing of components of TRRs and NFκB signaling modules in the surveillance of cell fitness during development. |
X Demographics
The data shown below were collected from the profiles of 61 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 25% |
| United Kingdom | 6 | 10% |
| France | 4 | 7% |
| Spain | 2 | 3% |
| Canada | 2 | 3% |
| Norway | 1 | 2% |
| Japan | 1 | 2% |
| India | 1 | 2% |
| Australia | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 25 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 39 | 64% |
| Scientists | 20 | 33% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 355 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 2% |
| Japan | 3 | <1% |
| France | 2 | <1% |
| Austria | 1 | <1% |
| China | 1 | <1% |
| Germany | 1 | <1% |
| Sweden | 1 | <1% |
| Philippines | 1 | <1% |
| Unknown | 337 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 95 | 27% |
| Researcher | 72 | 20% |
| Student > Master | 31 | 9% |
| Student > Bachelor | 29 | 8% |
| Professor > Associate Professor | 16 | 5% |
| Other | 51 | 14% |
| Unknown | 61 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 127 | 36% |
| Biochemistry, Genetics and Molecular Biology | 102 | 29% |
| Immunology and Microbiology | 14 | 4% |
| Medicine and Dentistry | 12 | 3% |
| Engineering | 10 | 3% |
| Other | 25 | 7% |
| Unknown | 65 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 112. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2016.
All research outputs
#366,609
of 25,085,910 outputs
Outputs from Science
#9,203
of 80,508 outputs
Outputs of similar age
#4,250
of 372,270 outputs
Outputs of similar age from Science
#124
of 839 outputs
Altmetric has tracked 25,085,910 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 80,508 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 372,270 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 839 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.