Title |
Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV/hepatitis C virus co-infection (C-WORTHY): a randomised, open-label phase 2 trial
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Published in |
The Lancet, November 2014
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DOI | 10.1016/s0140-6736(14)61793-1 |
Pubmed ID | |
Authors |
Mark Sulkowski, Christophe Hezode, Jan Gerstoft, John M Vierling, Josep Mallolas, Stanislas Pol, Marcelo Kugelmas, Abel Murillo, Nina Weis, Ronald Nahass, Oren Shibolet, Lawrence Serfaty, Marc Bourliere, Edwin DeJesus, Eli Zuckerman, Frank Dutko, Melissa Shaughnessy, Peggy Hwang, Anita Y M Howe, Janice Wahl, Michael Robertson, Eliav Barr, Barbara Haber |
Abstract |
Both hepatitis C virus (HCV) mono-infected and HIV/HCV co-infected patients are in need of safe, effective, all-oral HCV regimens. In a phase 2 study we aimed to assess the efficacy and safety of grazoprevir (MK-5172; HCV NS3/4A protease inhibitor) and two doses of elbasvir (MK-8742; HCV NS5A inhibitor) in patients with HCV mono-infection and HIV/HCV co-infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 15% |
France | 1 | 8% |
Canada | 1 | 8% |
Spain | 1 | 8% |
Japan | 1 | 8% |
Gibraltar | 1 | 8% |
Germany | 1 | 8% |
Unknown | 5 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 85% |
Practitioners (doctors, other healthcare professionals) | 2 | 15% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Italy | 1 | <1% |
France | 1 | <1% |
Unknown | 177 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 29 | 16% |
Student > Ph. D. Student | 25 | 14% |
Other | 23 | 13% |
Student > Master | 18 | 10% |
Student > Bachelor | 16 | 9% |
Other | 36 | 20% |
Unknown | 33 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 85 | 47% |
Agricultural and Biological Sciences | 10 | 6% |
Immunology and Microbiology | 8 | 4% |
Nursing and Health Professions | 6 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Other | 25 | 14% |
Unknown | 41 | 23% |