| Title |
Feasibility of Xpert Ebola Assay in Médecins Sans Frontières Ebola Program, Guinea
|
|---|---|
| Published in |
Emerging Infectious Diseases, February 2016
|
| DOI | 10.3201/eid2202.151238 |
| Pubmed ID | |
| Authors |
Rafael Van den Bergh, Pascale Chaillet, Mamadou Saliou Sow, Mathieu Amand, Charlotte van Vyve, Sylvie Jonckheere, Rosa Crestani, Armand Sprecher, Michel Van Herp, Arlene Chua, Erwan Piriou, Lamine Koivogui, Annick Antierens |
| Abstract |
Rapid diagnostic methods are essential in control of Ebola outbreaks and lead to timely isolation of cases and improved epidemiologic surveillance. Diagnosis during Ebola outbreaks in West Africa has relied on PCR performed in laboratories outside this region. Because time between sampling and PCR results can be considerable, we assessed the feasibility and added value of using the Xpert Ebola Assay in an Ebola control program in Guinea. A total of 218 samples were collected during diagnosis, treatment, and convalescence of patients. Median time for obtaining results was reduced from 334 min to 165 min. Twenty-six samples were positive for Ebola virus. Xpert cycle thresholds were consistently lower, and 8 (31%) samples were negative by routine PCR. Several logistic and safety issues were identified. We suggest that implementation of the Xpert Ebola Assay under programmatic conditions is feasible and represents a major advance in diagnosis of Ebola virus disease without apparent loss of assay sensitivity. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 44% |
| United Kingdom | 2 | 22% |
| France | 1 | 11% |
| Unknown | 2 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Canada | 1 | 1% |
| Unknown | 64 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 28% |
| Other | 11 | 16% |
| Student > Ph. D. Student | 6 | 9% |
| Student > Master | 5 | 7% |
| Student > Bachelor | 4 | 6% |
| Other | 13 | 19% |
| Unknown | 9 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 30% |
| Biochemistry, Genetics and Molecular Biology | 7 | 10% |
| Nursing and Health Professions | 7 | 10% |
| Agricultural and Biological Sciences | 7 | 10% |
| Veterinary Science and Veterinary Medicine | 3 | 4% |
| Other | 11 | 16% |
| Unknown | 12 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2015.
All research outputs
#4,494,683
of 24,486,486 outputs
Outputs from Emerging Infectious Diseases
#3,852
of 9,478 outputs
Outputs of similar age
#74,596
of 406,977 outputs
Outputs of similar age from Emerging Infectious Diseases
#64
of 129 outputs
Altmetric has tracked 24,486,486 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,478 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.5. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,977 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.