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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cellular GFP Toxicity and Immunogenicity: Potential Confounders in in Vivo Cell Tracking Experiments
|
|---|---|
| Published in |
Stem Cell Reviews and Reports, July 2016
|
| DOI | 10.1007/s12015-016-9670-8 |
| Pubmed ID | |
| Authors |
Amir Mehdi Ansari, A. Karim Ahmed, Aerielle E. Matsangos, Frank Lay, Louis J. Born, Guy Marti, John W. Harmon, Zhaoli Sun |
| Abstract |
Green Fluorescent protein (GFP), used as a cellular tag, provides researchers with a valuable method of measuring gene expression and cell tracking. However, there is evidence to suggest that the immunogenicity and cytotoxicity of GFP potentially confounds the interpretation of in vivo experimental data. Studies have shown that GFP expression can deteriorate over time as GFP tagged cells are prone to death. Therefore, the cells that were originally marked with GFP do not survive and cannot be accurately traced over time. This review will present current evidence for the immunogenicity and cytotoxicity of GFP in in vivo studies by characterizing these responses. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Canada | 1 | 17% |
| Germany | 1 | 17% |
| Venezuela, Bolivarian Republic of | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 67% |
| Members of the public | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 493 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Finland | 1 | <1% |
| India | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 489 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 82 | 17% |
| Student > Bachelor | 79 | 16% |
| Student > Master | 63 | 13% |
| Researcher | 53 | 11% |
| Student > Doctoral Student | 15 | 3% |
| Other | 41 | 8% |
| Unknown | 160 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 125 | 25% |
| Agricultural and Biological Sciences | 66 | 13% |
| Medicine and Dentistry | 36 | 7% |
| Neuroscience | 28 | 6% |
| Immunology and Microbiology | 22 | 4% |
| Other | 42 | 9% |
| Unknown | 174 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2023.
All research outputs
#1,472,303
of 25,374,647 outputs
Outputs from Stem Cell Reviews and Reports
#16
of 1,036 outputs
Outputs of similar age
#27,552
of 377,270 outputs
Outputs of similar age from Stem Cell Reviews and Reports
#2
of 13 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,036 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 377,270 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.