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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Role of Epigenetics in Aging and Autoimmunity
|
|---|---|
| Published in |
Clinical Reviews in Allergy & Immunology, August 2009
|
| DOI | 10.1007/s12016-009-8169-3 |
| Pubmed ID | |
| Authors |
Annabelle Grolleau-Julius, Donna Ray, Raymond L. Yung |
| Abstract |
The decline in immunocompetence with age is accompanied by the increase in the incidence of autoimmune diseases. Aging of the immune system, or immunosenescence, is characterized by a decline of both T and B cell function, and paradoxically the presence of low-grade chronic inflammation. There is growing evidence that epigenetics, the study of inherited changes in gene expression that are not encoded by the DNA sequence itself, changes with aging. Interestingly, emerging evidence suggests a key role for epigenetics in human pathologies, including inflammatory and neoplastic disorders. Here, we will review the potential mechanisms that contribute to the increase in autoimmune responses in aging. In particular, we will discuss how epigenetic alterations, especially DNA methylation and histone acetylation, are accumulated during aging and how these events contribute to autoimmunity risk. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 5 | 4% |
| United States | 3 | 2% |
| Japan | 2 | 2% |
| Denmark | 1 | <1% |
| Italy | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 117 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 21% |
| Student > Ph. D. Student | 21 | 16% |
| Student > Bachelor | 19 | 15% |
| Student > Master | 13 | 10% |
| Other | 8 | 6% |
| Other | 30 | 23% |
| Unknown | 13 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 41 | 31% |
| Biochemistry, Genetics and Molecular Biology | 24 | 18% |
| Medicine and Dentistry | 23 | 18% |
| Immunology and Microbiology | 5 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Other | 14 | 11% |
| Unknown | 19 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2013.
All research outputs
#15,729,845
of 23,975,976 outputs
Outputs from Clinical Reviews in Allergy & Immunology
#503
of 690 outputs
Outputs of similar age
#96,796
of 114,431 outputs
Outputs of similar age from Clinical Reviews in Allergy & Immunology
#12
of 14 outputs
Altmetric has tracked 23,975,976 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 690 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,431 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.