Title |
Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett's oesophagus
|
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Published in |
Gut, December 2012
|
DOI | 10.1136/gutjnl-2012-303594 |
Pubmed ID | |
Authors |
Florine Kastelein, Katharina Biermann, Ewout W Steyerberg, Joanne Verheij, Marit Kalisvaart, Leendert H J Looijenga, Hans A Stoop, Laurens Walter, Ernst J Kuipers, Manon C W Spaander, Marco J Bruno, on behalf of the ProBar-study group |
Abstract |
The value of surveillance for patients with Barrett's oesophagus (BO) is under discussion given the overall low incidence of neoplastic progression and lack of discriminative tests for risk stratification. Histological diagnosis of low-grade dysplasia (LGD) is the only accepted predictor for progression to date, but has a low predictive value. The aim of this study was therefore to evaluate the value of p53 immunohistochemistry for predicting neoplastic progression in patients with BO. |
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Geographical breakdown
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Belgium | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
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Scientists | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
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Student > Ph. D. Student | 17 | 20% |
Student > Master | 9 | 10% |
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Unknown | 20 | 23% |