Title |
Complement evasion by Borrelia burgdorferi: it takes three to tango
|
---|---|
Published in |
Trends in Parasitology, January 2013
|
DOI | 10.1016/j.pt.2012.12.001 |
Pubmed ID | |
Authors |
Steven W. de Taeye, Lieselotte Kreuk, Alje P. van Dam, Joppe W. Hovius, Tim J. Schuijt |
Abstract |
The complement system is one of the major innate defense mechanisms Borrelia burgdorferi sensu lato has to overcome to establish an infection of mammalian hosts and to cause Lyme borreliosis in humans. Borrelia prevents complement-mediated killing during host colonization through (i) recruitment of host complement regulators by Borrelia, (ii) evasion mechanisms by Borrelia itself, and (iii) exploitation of tick proteins by Borrelia. These interactions with complement can be host species-specific. This review provides an overview of interactions between Borrelia, tick, and host leading to evasion of complement-mediated killing. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 50% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | <1% |
Germany | 1 | <1% |
Unknown | 141 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 35 | 24% |
Student > Bachelor | 23 | 16% |
Researcher | 19 | 13% |
Student > Master | 18 | 13% |
Other | 7 | 5% |
Other | 21 | 15% |
Unknown | 20 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 44 | 31% |
Biochemistry, Genetics and Molecular Biology | 23 | 16% |
Medicine and Dentistry | 17 | 12% |
Immunology and Microbiology | 16 | 11% |
Veterinary Science and Veterinary Medicine | 6 | 4% |
Other | 12 | 8% |
Unknown | 25 | 17% |