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β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology

Overview of attention for article published in Cell Research, December 2012
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Title
β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology
Published in
Cell Research, December 2012
DOI 10.1038/cr.2012.167
Pubmed ID
Authors

Xiaosong Liu, Xiaohui Zhao, Xianglu Zeng, Koen Bossers, Dick F Swaab, Jian Zhao, Gang Pei

Abstract

Alzheimer's disease (AD) is a progressive and complex neurodegenerative disease in which the γ-secretase-mediated amyloid-β (Aβ) pathology plays an important role. We found that a multifunctional protein, β-arrestin1, facilitated the formation of NCT/APH-1 (anterior pharynx-defective phenotype 1) precomplex and mature γ-secretase complex through its functional interaction with APH-1. Deficiency of β-arrestin1 or inhibition of binding of β-arrestin1 with APH-1 by small peptides reduced Aβ production without affecting Notch processing. Genetic ablation of β-arrestin1 diminished Aβ pathology and behavioral deficits in transgenic AD mice. Moreover, in brains of sporadic AD patients and transgenic AD mice, the expression of β-arrestin1 was upregulated and correlated well with neuropathological severity and senile Aβ plaques. Thus, our study identifies a regulatory mechanism underlying both γ-secretase assembly and AD pathogenesis, and indicates that specific reduction of Aβ pathology can be achieved by regulation of the γ-secretase assembly.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 46 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 17%
Student > Ph. D. Student 8 17%
Researcher 6 13%
Student > Bachelor 5 11%
Student > Doctoral Student 4 9%
Other 8 17%
Unknown 8 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 19%
Agricultural and Biological Sciences 8 17%
Neuroscience 7 15%
Pharmacology, Toxicology and Pharmaceutical Science 4 9%
Chemistry 3 6%
Other 7 15%
Unknown 9 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2013.
All research outputs
#15,260,208
of 22,691,736 outputs
Outputs from Cell Research
#1,516
of 1,870 outputs
Outputs of similar age
#179,377
of 277,760 outputs
Outputs of similar age from Cell Research
#16
of 27 outputs
Altmetric has tracked 22,691,736 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,870 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,760 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.