Title |
Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein
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Published in |
European Heart Journal, January 2013
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DOI | 10.1093/eurheartj/ehs472 |
Pubmed ID | |
Authors |
Vincenzo Sorrentino, Sigrid W. Fouchier, Mohammad M. Motazacker, Jessica K. Nelson, Joep C. Defesche, Geesje M. Dallinga-Thie, John J.P. Kastelein, G. Kees Hovingh, Noam Zelcer |
Abstract |
Recent genome-wide association studies suggest that IDOL (also known as MYLIP) contributes to variation in circulating levels of low-density lipoprotein cholesterol (LDL-C). IDOL, an E3-ubiquitin ligase, is a recently identified post-transcriptional regulator of LDLR abundance. Briefly, IDOL promotes degradation of the LDLR thereby limiting LDL uptake. Yet the exact role of IDOL in human lipoprotein metabolism is unclear. Therefore, this study aimed at identifying and functionally characterizing IDOL variants in the Dutch population and to assess their contribution to circulating levels of LDL-C. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
Unknown | 53 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 24% |
Student > Ph. D. Student | 9 | 17% |
Student > Master | 5 | 9% |
Student > Bachelor | 5 | 9% |
Professor | 3 | 6% |
Other | 9 | 17% |
Unknown | 10 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 30% |
Biochemistry, Genetics and Molecular Biology | 10 | 19% |
Agricultural and Biological Sciences | 7 | 13% |
Unspecified | 1 | 2% |
Psychology | 1 | 2% |
Other | 3 | 6% |
Unknown | 16 | 30% |