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Mendeley readers
Attention Score in Context
| Title |
Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits
|
|---|---|
| Published in |
Archives of Pharmacal Research, April 2010
|
| DOI | 10.1007/s12272-010-0420-1 |
| Pubmed ID | |
| Authors |
Manar A. Nader, Dina S. El-Agamy, Ghada M. Suddek |
| Abstract |
Hypercholesterolemia, cholesterol-enriched diet and oxidative stress have been shown to increase serum total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) levels resulting in development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging free radicals, thus providing protection to humans against infectious and degenerative diseases. The present study was undertaken to examine the possible protective effects of propolis (a resinous hive product collected by honeybees from various plant sources) and thymoquinone (TQ, active constituent of Nigella. Sativa seeds oil) on serum lipid levels and early atherosclerotic lesions in hypercholestrolemic rabbits. New Zealand rabbits were fed on either standard chow or atherogenic diet during four weeks and concomitantly received either propolis or TQ. At the end of experiment period, serum samples were collected to determine lipid profile, kidney functions and antioxidant status. Tissues from aorta, pulmonary artery and kidney were taken for histopathological examination. The cholesterol-enriched diet induced a significant increase in serum TC, triglycerides, LDL-C, thiobarbituric acid-reactive substances concentrations and a significant decrease in high density lipoprotein-cholesterol and in reduced glutathione levels compared to control group. Administration of propolis or TQ with cholesterol-enriched diet significantly (p < 0.05) reduced TC, LDL-C, triglycerides and thiobarbituric acid-reactive substances concentrations, while increased high density lipoprotein-cholesterol concentration, as well as glutathione content compared to high cholesterol (HC) control group. Kidney function parameters were significantly affected by cholesterol diet and both propolis and TQ counterregulated the cholesterol-induced changes. Histopathologically, early atherosclerotic changes were observed in HC control group represented by endothelial damage and thickened foam cells while propolis or TQ provided protection against the HC-induced damage. In conclusion, the present study suggests the potential beneficial effects of both propolis and TQ in diminishing the risk of atherosclerosis via antioxidant mechanism. |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Philippines | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 102 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 15% |
| Student > Master | 15 | 14% |
| Student > Bachelor | 7 | 7% |
| Unspecified | 6 | 6% |
| Lecturer | 6 | 6% |
| Other | 21 | 20% |
| Unknown | 34 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 14% |
| Agricultural and Biological Sciences | 10 | 10% |
| Biochemistry, Genetics and Molecular Biology | 9 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 8% |
| Unspecified | 6 | 6% |
| Other | 18 | 17% |
| Unknown | 39 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2013.
All research outputs
#20,180,477
of 22,694,633 outputs
Outputs from Archives of Pharmacal Research
#1,132
of 1,292 outputs
Outputs of similar age
#90,919
of 95,406 outputs
Outputs of similar age from Archives of Pharmacal Research
#19
of 21 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,292 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,406 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.