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Langerhans Cells Favor Skin Flora Tolerance through Limited Presentation of Bacterial Antigens and Induction of Regulatory T Cells

Overview of attention for article published in Journal of Investigative Dermatology, February 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

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Title
Langerhans Cells Favor Skin Flora Tolerance through Limited Presentation of Bacterial Antigens and Induction of Regulatory T Cells
Published in
Journal of Investigative Dermatology, February 2013
DOI 10.1038/jid.2012.500
Pubmed ID
Authors

Angelic M.G. van der Aar, Daisy I. Picavet, Femke J. Muller, Leonie de Boer, Toni M.M. van Capel, Sebastian A.J. Zaat, Jan D. Bos, Hans Janssen, Thaddeus C. George, Martien L. Kapsenberg, S Marieke van Ham, Marcel B.M. Teunissen, Esther C. de Jong

Abstract

The mechanisms preventing detrimental T-cell responses against commensal skin bacteria remain elusive. Using monocyte-derived and skin-derived dendritic cells (DCs), we demonstrate that epidermal Langerhans cells (LCs), the DCs in the most superficial layer of the skin, have a poor capacity to internalize bacteria because of low expression of FcγRIIa. Furthermore, LCs show deficiency in processing and major histocompatibility complex II (MHC-II)-restricted presentation of bacterial antigens, as a result of a decreased expression of molecules involved in these functionalities. The reduced capacity to take up, process, and present bacterial antigens cannot be restored by LC activation by ectopically expressed Toll-like receptors or by cytokines. Consequently, bacteria-primed LCs poorly restimulate antibacterial memory CD4(+) T cells and inefficiently induce bacteria-specific effector CD4(+) T cells from naive T cells; however, they initiate the development of regulatory Foxp3(+)CD4(+) T cells, which are able to suppress the proliferation of autologous bystander T cells specific for the same bacteria. In contrast, dermal DCs that reside in the deeper dermal layer of the skin efficiently present bacterial antigens and provoke robust antibacterial naive and memory CD4(+) T-cell responses. In conclusion, LCs form a unique DC subset that is adapted at multiple levels for the maintenance of tolerance to bacterial skin flora.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 <1%
Denmark 1 <1%
Brazil 1 <1%
Unknown 107 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 22%
Researcher 24 22%
Student > Master 11 10%
Student > Bachelor 7 6%
Professor > Associate Professor 6 5%
Other 15 14%
Unknown 23 21%
Readers by discipline Count As %
Immunology and Microbiology 29 26%
Agricultural and Biological Sciences 20 18%
Medicine and Dentistry 19 17%
Biochemistry, Genetics and Molecular Biology 13 12%
Environmental Science 1 <1%
Other 2 2%
Unknown 26 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2013.
All research outputs
#1,568,521
of 25,371,288 outputs
Outputs from Journal of Investigative Dermatology
#351
of 8,994 outputs
Outputs of similar age
#14,401
of 291,023 outputs
Outputs of similar age from Journal of Investigative Dermatology
#6
of 95 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,994 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,023 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.