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Identification of a Genetic Determinant in Clinical Enterococcus faecium Strains That Contributes to Intestinal Colonization During Antibiotic Treatment

Overview of attention for article published in Journal of Infectious Diseases, February 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

twitter
4 X users
peer_reviews
1 peer review site

Citations

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78 Dimensions

Readers on

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80 Mendeley
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Title
Identification of a Genetic Determinant in Clinical Enterococcus faecium Strains That Contributes to Intestinal Colonization During Antibiotic Treatment
Published in
Journal of Infectious Diseases, February 2013
DOI 10.1093/infdis/jit076
Pubmed ID
Authors

Xinglin Zhang, Janetta Top, Mark de Been, Damien Bierschenk, Malbert Rogers, Masja Leendertse, Marc J. M. Bonten, Tom van der Poll, Rob J. L. Willems, Willem van Schaik

Abstract

Intestinal colonization by antibiotic-resistant Enterococcus faecium is the first step in a process that can lead to infections in hospitalized patients. By comparative genome analysis and subsequent polymerase chain reaction screening, we identified a locus that encodes a putative phosphotransferase system (PTS). The PTS locus was widespread in isolates from hospital outbreaks of infection (84.2%) and nonoutbreak clinical infections (66.0%) but absent from human commensal isolates. Deletion of pstD, which is predicted to encode the enzyme IID subunit of this PTS, significantly impaired the ability of E. faecium to colonize the murine intestinal tract during antibiotic treatment. This is the first description of a determinant that contributes to intestinal colonization in clinical E. faecium strains.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 79 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 31%
Student > Ph. D. Student 12 15%
Student > Bachelor 6 8%
Student > Master 5 6%
Student > Postgraduate 3 4%
Other 7 9%
Unknown 22 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 23%
Biochemistry, Genetics and Molecular Biology 11 14%
Immunology and Microbiology 8 10%
Medicine and Dentistry 4 5%
Veterinary Science and Veterinary Medicine 3 4%
Other 12 15%
Unknown 24 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2015.
All research outputs
#8,018,210
of 25,529,543 outputs
Outputs from Journal of Infectious Diseases
#6,728
of 14,836 outputs
Outputs of similar age
#63,775
of 205,514 outputs
Outputs of similar age from Journal of Infectious Diseases
#40
of 90 outputs
Altmetric has tracked 25,529,543 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 14,836 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.5. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,514 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.