Title |
Identification of a Genetic Determinant in Clinical Enterococcus faecium Strains That Contributes to Intestinal Colonization During Antibiotic Treatment
|
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Published in |
Journal of Infectious Diseases, February 2013
|
DOI | 10.1093/infdis/jit076 |
Pubmed ID | |
Authors |
Xinglin Zhang, Janetta Top, Mark de Been, Damien Bierschenk, Malbert Rogers, Masja Leendertse, Marc J. M. Bonten, Tom van der Poll, Rob J. L. Willems, Willem van Schaik |
Abstract |
Intestinal colonization by antibiotic-resistant Enterococcus faecium is the first step in a process that can lead to infections in hospitalized patients. By comparative genome analysis and subsequent polymerase chain reaction screening, we identified a locus that encodes a putative phosphotransferase system (PTS). The PTS locus was widespread in isolates from hospital outbreaks of infection (84.2%) and nonoutbreak clinical infections (66.0%) but absent from human commensal isolates. Deletion of pstD, which is predicted to encode the enzyme IID subunit of this PTS, significantly impaired the ability of E. faecium to colonize the murine intestinal tract during antibiotic treatment. This is the first description of a determinant that contributes to intestinal colonization in clinical E. faecium strains. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Scientists | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 1% |
Unknown | 79 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 25 | 31% |
Student > Ph. D. Student | 12 | 15% |
Student > Bachelor | 6 | 8% |
Student > Master | 5 | 6% |
Student > Postgraduate | 3 | 4% |
Other | 7 | 9% |
Unknown | 22 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 23% |
Biochemistry, Genetics and Molecular Biology | 11 | 14% |
Immunology and Microbiology | 8 | 10% |
Medicine and Dentistry | 4 | 5% |
Veterinary Science and Veterinary Medicine | 3 | 4% |
Other | 12 | 15% |
Unknown | 24 | 30% |