Title |
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
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Published in |
Nature Immunology, January 2013
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DOI | 10.1038/ni.2534 |
Pubmed ID | |
Authors |
Jochem H Bernink, Charlotte P Peters, Marius Munneke, Anje A te Velde, Sybren L Meijer, Kees Weijer, Hulda S Hreggvidsdottir, Sigrid E Heinsbroek, Nicolas Legrand, Christianne J Buskens, Willem A Bemelman, Jenny M Mjösberg, Hergen Spits |
Abstract |
Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T(H)2, T(H)17 and T(H)22. Here we describe a distinct ILC subset similar to T(H)1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ). ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from RORγt(+) ILC3 under the influence of IL-12. The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing ILC1 cells in the pathogenesis of gut mucosal inflammation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | <1% |
United Kingdom | 3 | <1% |
Germany | 2 | <1% |
Netherlands | 2 | <1% |
Canada | 2 | <1% |
Austria | 1 | <1% |
France | 1 | <1% |
Spain | 1 | <1% |
Peru | 1 | <1% |
Other | 2 | <1% |
Unknown | 648 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 154 | 23% |
Researcher | 115 | 17% |
Student > Master | 97 | 14% |
Student > Bachelor | 69 | 10% |
Student > Doctoral Student | 32 | 5% |
Other | 89 | 13% |
Unknown | 113 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 176 | 26% |
Agricultural and Biological Sciences | 172 | 26% |
Medicine and Dentistry | 83 | 12% |
Biochemistry, Genetics and Molecular Biology | 79 | 12% |
Neuroscience | 6 | <1% |
Other | 26 | 4% |
Unknown | 127 | 19% |