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Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

Overview of attention for article published in Nature Immunology, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

news
1 news outlet
twitter
3 X users
patent
3 patents
wikipedia
1 Wikipedia page

Citations

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847 Dimensions

Readers on

mendeley
669 Mendeley
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1 CiteULike
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Title
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
Published in
Nature Immunology, January 2013
DOI 10.1038/ni.2534
Pubmed ID
Authors

Jochem H Bernink, Charlotte P Peters, Marius Munneke, Anje A te Velde, Sybren L Meijer, Kees Weijer, Hulda S Hreggvidsdottir, Sigrid E Heinsbroek, Nicolas Legrand, Christianne J Buskens, Willem A Bemelman, Jenny M Mjösberg, Hergen Spits

Abstract

Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T(H)2, T(H)17 and T(H)22. Here we describe a distinct ILC subset similar to T(H)1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ). ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from RORγt(+) ILC3 under the influence of IL-12. The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-γ-producing ILC1 cells in the pathogenesis of gut mucosal inflammation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 669 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 <1%
United Kingdom 3 <1%
Germany 2 <1%
Netherlands 2 <1%
Canada 2 <1%
Austria 1 <1%
France 1 <1%
Spain 1 <1%
Peru 1 <1%
Other 2 <1%
Unknown 648 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 154 23%
Researcher 115 17%
Student > Master 97 14%
Student > Bachelor 69 10%
Student > Doctoral Student 32 5%
Other 89 13%
Unknown 113 17%
Readers by discipline Count As %
Immunology and Microbiology 176 26%
Agricultural and Biological Sciences 172 26%
Medicine and Dentistry 83 12%
Biochemistry, Genetics and Molecular Biology 79 12%
Neuroscience 6 <1%
Other 26 4%
Unknown 127 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2022.
All research outputs
#1,632,516
of 23,299,593 outputs
Outputs from Nature Immunology
#944
of 3,859 outputs
Outputs of similar age
#16,633
of 288,141 outputs
Outputs of similar age from Nature Immunology
#11
of 44 outputs
Altmetric has tracked 23,299,593 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,859 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.3. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,141 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.