Title |
Protease-Activated Receptor (PAR)2, but Not PAR1, Is Involved in Collateral Formation and Anti-Inflammatory Monocyte Polarization in a Mouse Hind Limb Ischemia Model
|
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Published in |
PLOS ONE, April 2013
|
DOI | 10.1371/journal.pone.0061923 |
Pubmed ID | |
Authors |
Lisa G. van den Hengel, Alwine A. Hellingman, Anne Yael Nossent, Annemarie M. van Oeveren-Rietdijk, Margreet R. de Vries, C. Arnold Spek, Anton Jan van Zonneveld, Pieter H. Reitsma, Jaap F. Hamming, Hetty C. de Boer, Henri H. Versteeg, Paul H. A. Quax |
Abstract |
In collateral development (i.e. arteriogenesis), mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR)1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in arteriogenesis in a murine hind limb ischemia model. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Czechia | 1 | 3% |
Unknown | 36 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 22% |
Student > Ph. D. Student | 7 | 19% |
Student > Master | 5 | 14% |
Professor | 4 | 11% |
Student > Bachelor | 3 | 8% |
Other | 4 | 11% |
Unknown | 6 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 30% |
Medicine and Dentistry | 9 | 24% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Immunology and Microbiology | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Other | 0 | 0% |
Unknown | 8 | 22% |