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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Malignancies and monoclonal gammopathy in Gaucher disease; a systematic review of the literature
|
|---|---|
| Published in |
British Journal of Haematology, April 2013
|
| DOI | 10.1111/bjh.12335 |
| Pubmed ID | |
| Authors |
Maarten Arends, Laura van Dussen, Marieke Biegstraaten, Carla E. M. Hollak |
| Abstract |
Gaucher disease is an autosomal, recessively inherited, lysosomal storage disease, which has been associated with gammopathies and malignancies. This report represents the results of a systematic review of the literature on the prevalence of monoclonal gammopathies and malignancies in Gaucher disease. A PubMed search identified 365 studies, of which 80 reported on concomitant Gaucher disease and malignancies and/or gammopathies (15 cohort/cross sectional studies, and 65 case reports/series). Based on these studies, we conclude that compared to the general population, Gaucher patients have an increased risk of cancer in general [pooled relative risk of 1·70 (95% confidence interval 1·27-2·31)], and multiple myeloma and haematological malignancies in particular (estimated risk between 25·0 and 51·1 and 3·5 and 12·7, respectively). In addition, an increased risk has been reported for hepatocellular carcinoma and renal cell carcinoma. Several factors have been hypothesized to play a role in the pathophysiology. These include: splenectomy, immune dysregulation, endoplasmic reticulum stress, genetic modifiers, altered iron metabolism and insulin resistance. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 1% |
| Unknown | 86 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 24% |
| Other | 13 | 15% |
| Student > Ph. D. Student | 13 | 15% |
| Student > Master | 9 | 10% |
| Student > Postgraduate | 8 | 9% |
| Other | 10 | 11% |
| Unknown | 13 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 44 | 51% |
| Agricultural and Biological Sciences | 9 | 10% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Business, Management and Accounting | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 14 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2022.
All research outputs
#7,109,844
of 24,712,008 outputs
Outputs from British Journal of Haematology
#2,619
of 7,976 outputs
Outputs of similar age
#56,314
of 201,710 outputs
Outputs of similar age from British Journal of Haematology
#20
of 63 outputs
Altmetric has tracked 24,712,008 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 7,976 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,710 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.